Factors affecting intellectual outcome in pediatric brain tumor patients
A prospective study utilizing repeated intellectual testing was undertaken in 73 children with brain tumors consecutively admitted to Childrens Hospital of Los Angeles over a 3-year period to determine the effect of tumor location, extent of surgical resection, hydrocephalus, age of the child, radiation therapy, and chemotherapy on cognitive outcome. Forty-three patients were followed for at least two sequential intellectual assessments and provide the data for this study. Children with hemispheric tumors had the most general cognitive impairment. The degree of tumor resection, adequately treated hydrocephalus, and chemotherapy had no bearing on intellectual outcome. Age of the child affected outcome mainly as it related to radiation. Whole brain radiation therapy was associated with cognitive decline. This was especially true in children below 7 years of age, who experienced a very significant loss of function after whole brain radiation therapy.
- OSTI ID:
- 5470111
- Journal Information:
- Neurosurgery; (United States), Vol. 21:5
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BRAIN
NEOPLASMS
COMBINED THERAPY
SIDE EFFECTS
AGE DEPENDENCE
CHILDREN
PATIENTS
AGE GROUPS
BODY
CENTRAL NERVOUS SYSTEM
DISEASES
NERVOUS SYSTEM
ORGANS
THERAPY
550602* - Medicine- External Radiation in Diagnostics- (1980-)
550600 - Medicine
560151 - Radiation Effects on Animals- Man