Delayed blood regeneration in lead exposure: An effect on reserve capacity
- Odense Univ. (Denmark)
Twenty-five lead-exposed Danish battery production workers and 25-age-matched controls were examined to evaluate subclinical effects on blood formation. Blood lead levels averaged 2.14 mumol/L and 0.35 mumol/L in the two groups; the lead workers also showed high levels of erythrocyte protoporphyrin, as compared to the controls. Otherwise, the hematological parameters indicated an appropriate iron status and no other deviations. From all subjects, 0.45 L of blood was bled as part of a normal blood donation. Five and 11 days later, reticulocyte counts were significantly higher in the control group than in the lead-exposed workers. On day 15, the lead workers showed a significant delay in blood regeneration, as evidenced by lower hemoglobin concentration, and erythrocyte and reticulocyte counts. The lead exposure in the present study was within legal limits, and lead-induced anemia would be expected only at much higher exposure levels. Thus, despite the normal hematological findings in the initial examination, the lead exposure caused a decreased reserve capacity for blood formation, and this effect became evident only after the blood loss.
- OSTI ID:
- 5465732
- Journal Information:
- American Journal of Public Health; (USA), Vol. 79:10; ISSN 0090-0036
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
LEAD
TOXICITY
BLOOD COUNT
BLOOD FORMATION
DENMARK
ERYTHROCYTES
HEMOGLOBIN
OCCUPATIONAL EXPOSURE
PERSONNEL
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOXYLIC ACIDS
ELEMENTS
EUROPE
GLOBINS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
MATERIALS
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
PORPHYRINS
PROTEINS
SCANDINAVIA
560300* - Chemicals Metabolism & Toxicology