A noninvasive scintigraphic assessment of the colonic transit of nondigestible solids in man
- Department of Nuclear Engineering, General Clinical Research Center, University of Virginia, Charlottesville (USA)
A noninvasive, scintigraphic technique for quantifying large intestinal transit time that provides low radiation doses was developed. The scintigraphic large intestinal transit (SLIT) method uses a total of 100 microCi of 111In encapsulated in ten 2-cm nondigestible capsules, which are ingested after a 6-hr fast. Two hundred fifty microcuries of 99mTc-sulfur colloid were given to outline the gastrointestinal tract. Images were acquired at 4-hr intervals until all capsules were excreted. Normal volunteers (n = 10) consumed a standardized diet 2 days prior and during imaging. Segmental transit times were measured in the following: ascending, transverse, descending, recto-sigmoid colons; hepatic and splenic flexures. The radiation absorbed dose to the large intestine for the SLIT technique is less than half of that associated with other radiographic methods of colonic transit time measurement.
- OSTI ID:
- 5462141
- Journal Information:
- Journal of Nuclear Medicine; (United States), Vol. 32:7; ISSN 0161-5505
- Country of Publication:
- United States
- Language:
- English
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LARGE INTESTINE
SCINTISCANNING
CAPSULES
COLLOIDS
DTPA
DYNAMIC FUNCTION STUDIES
INDIUM 111
ISOMERIC NUCLEI
LOW DOSE IRRADIATION
MAN
TECHNETIUM 99
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
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DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISPERSIONS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GASTROINTESTINAL TRACT
HOURS LIVING RADIOISOTOPES
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
INTESTINES
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PRIMATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOI
550601* - Medicine- Unsealed Radionuclides in Diagnostics