Effect of lowered vitamin D binding protein levels on the biological activity and metabolism of 1,25-dihydroxyvitamin D/sub 3/

Conference · Sat Mar 01 00:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:5461874

Kost, S B; Londowski, J; Audran, M; Kumar, R

The authors studied the effect of lowered vitamin D binding protein levels on the biological activity and metabolism of 1,25-dihydroxyvitamin D/sub 3/ (1,25(OH)/sub 2/D/sub 3/) in vivo. Estrogen administration to vitamin D-deficient rats resulted in decrease of plasma vitamin D binding protein concentrations by about 20%. The authors administered graded doses of 1,25(OH)/sub 2/D/sub 3/ (5 - 5000 pmol intravenously) to vitamin D-deficient rats given estrogen or vehicle, and studied the biological response in intestine and bone. Intestinal calcium transport, following the administration of 1,25(OH)/sub 2/D/sub 3/, was similar in the estrogen or vehicle-treated groups. Serum calcium concentrations were lower in the estrogen-treated rats when compared to rats given vehicle. Serum calcium in both groups, however, increased the same amount over the range of 1,25(OH)/sub 2/D/sub 3/ given. The uptake of (/sup 3/H) 1,25(OH)/sub 2/D/sub 3/ by the intestine and bone 8 hours after the administration of (/sup 3/H) 1,25(OH)/sub 2/D/sub 3/ was similar in estrogen- and vehicle-treated rats. The amount of (/sup 3/H) 1,25(OH)/sub 2/D/sub 3/ in plasma of estrogen-treated rats was the same as in vehicle-treated rats. The authors conclude that in estrogen-treated rats, lowered vitamin D binding protein levels do not alter the effect of 1,25(OH)/sub 2/D/sub 3/ on intestine or bone and do not alter the metabolism of 1,25(OH)/sub 2/D/sub 3/.

• Research Organization: Mayo Clinic and Foundation, Rochester, MN
• OSTI ID: 5461874
• Report Number(s): CONF-8604222-; TRN: 86-028415
• Journal Information: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:3; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CALCIUM
MEMBRANE TRANSPORT
CHOLECALCIFEROL
METABOLISM
PROTEINS
BIOLOGICAL EFFECTS
ESTROGENS
NUTRITIONAL DEFICIENCY
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VITAMIN D
ALKALINE EARTH METALS
ELEMENTS
HORMONES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
METALS
ORGANIC COMPOUNDS
STEROID HORMONES
VITAMINS
550501* - Metabolism- Tracer Techniques