Immunization against strontium-90 induction of bone tumors with inactivated FBJ virus and irradiated syngeneic strontium-90-induced tumor cells
Three hundred six C57BL/6J female mice were subdivided into a control group left untreated and an experimental group treated intraperitoneally with 1.0 ..mu..Ci strontium-90/g of body weight at an age of 66 days. Treatments for the groups were as follows: none, 6 injections of formalin-inactivated FBJ viral preparation, 6 injections of active FBJ viral preparation, and 2 injections of 10,000 rad irradiated transplantable osteosarcoma previously induced in C57BL/6J mice by strontium-90. In addition to the above groups, two other groups were treated with respectively 0.032 and 0.10 ..mu..Ci strontium-90/g body weight in order to obtain information on the dose-response relationship between the injection of strontium-90 and the yield of bone tumors. In the groups not treated with strontium-90, only 1 bone tumor developed; this occurred in the group injected with FBJ virus. The incidence of bone tumors in the groups treated with 1.0 ..mu..Ci strontium-90 was significantly lower (18.5% or 18.2%) in the two groups that had received injections of inactivated FBJ virus or irradiated isogenic osteosarcoma when compared to the group left uninjected, which developed 43.5% tumors. In contrast, the strontium-90-treated group that also received injections of active FBJ virus developed 63.0% tumors. Only a single bone tumor developed in the groups treated solely with intermediate doses of strontium-90. The results indicate that immunization with inactivated FBJ virus or with irradiated syngeneic strontium-90-induced tumor cells can significantly decrease the development of strontium-90-induced tumors.
- Research Organization:
- Mallory Inst. of Pathology Research Foundation, Boston, MA (USA); Boston Univ., MA (USA). School of Medicine; Boston City Hospital, MA (USA); Veterans Administration Hospital, Boston, MA (USA)
- DOE Contract Number:
- AS02-76EV02539
- OSTI ID:
- 5456923
- Report Number(s):
- DOE/EV/02539-40; COO-2539-40; ON: DE82011951
- Resource Relation:
- Other Information: Portions of document are illegible
- Country of Publication:
- United States
- Language:
- English
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OSTEOSARCOMAS
RADIOINDUCTION
SKELETON
BIOLOGICAL RADIATION EFFECTS
STRONTIUM 90
CARCINOGENESIS
TUMOR CELLS
RADIOSENSITIVITY EFFECTS
TUMOR PROMOTERS
VIRUSES
FEMALES
IMMUNITY
INACTIVATION
INTRAPERITONEAL INJECTION
MICE
ALKALINE EARTH ISOTOPES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
DISEASES
EVEN-EVEN NUCLEI
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
MICROORGANISMS
NEOPLASMS
NUCLEI
ORGANS
PARASITES
PATHOGENESIS
PROMOTERS
RADIATION EFFECTS
RADIOISOTOPES
RODENTS
SARCOMAS
SKELETAL DISEASES
STRONTIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560162* - Radionuclide Effects
Kinetics
& Toxicology- Animals
Plants
Microorganisms
& Cells