Effect of alcohol consumption on selenium (Se) bioavailability in rats
This study was done to determine the effects of alcohol ingestion on Se bioavailability in initially Se-depleted rats. Weanling male rats were fed a Se deficient (0.012 mg/kg) basal diet for 4 weeks and then for the subsequent 4 weeks were supplemented at 0.031 mg Se/kg or at 0.085 mg Se/kg of diet in the form of high Se yeast. During the Se repletion period alcohol replaced medium chain triglycerides in the diet at 3 levels: 0%, 10%, and 20% of calories. Dietary Se level significantly (P < .0001) affected urinary Se, fecal Se, Se absorption, Se balance, whole blood Se, whole blood glutathione peroxidase activity, and liver Se. In rats fed the higher Se diet total liver Se increased 50% when 20% rather than 0% alcohol was given. In rats fed the lower Se diet total liver Se decreased 12% as dietary alcohol increased from 0 to 20%. There was a significant (P < .0015) interaction between alcohol and Se level. All the other parameters for Se bioavailability were not affected by alcohol consumption. However, alcohol consumption significantly reduced growth rate at both Se levels.
- Research Organization:
- Ohio State Univ., Columbus
- OSTI ID:
- 5456193
- Report Number(s):
- CONF-8604222-
- Journal Information:
- Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:3; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ALCOHOLS
BIOLOGICAL EFFECTS
SELENIUM
BIOLOGICAL AVAILABILITY
BLOOD
DIET
ENZYME ACTIVITY
FECES
INGESTION
LIVER
NUTRITIONAL DEFICIENCY
PEROXIDASES
RATS
URINE
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
DIGESTIVE SYSTEM
ELEMENTS
ENZYMES
GLANDS
HYDROXY COMPOUNDS
INTAKE
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
RODENTS
SEMIMETALS
VERTEBRATES
WASTES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)