Iodination of organic compounds via organoborane intermediates: new methods

Thesis/Dissertation · Thu Jan 01 00:00:00 EST 1981

OSTI ID:5453195

Gooch, III, E E

The incorporation of iodine into organic molecules can be accomplished through the use of organoboranes as synthetic intermediates. However, the iodination of organoboranes with molecular iodine is not suitable for the efficient incorporation of radioiodine into organic molecules since one-half of the radionuclide is lost as iodide. The iodination of organoboranes, vinylboronic acids and arylboronic acids was studied, using iodine monochloride or sodium iodide/chloramine-T. Both synthetic methods were rapid and efficient methods for iodinating organic substrates, including those with functional groups. The reactions provided maximum utilization of radioiodine in the synthesis of iodine-125 labeled compounds, both in preliminary tracer studies, and in experiments using carrier-free iodine-125.

• Research Organization: Tennessee Univ., Knoxville (USA)
• OSTI ID: 5453195
• Resource Relation: Other Information: Thesis (Ph. D.)
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
BORANES
IODINATION
IODINE 125
RADIOCHEMISTRY
ORGANIC COMPOUNDS
ORGANOMETALLIC COMPOUNDS
LABELLED COMPOUNDS
LABELLING
BETA DECAY RADIOISOTOPES
BORON COMPOUNDS
CHEMICAL REACTIONS
CHEMISTRY
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
HALOGENATION
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
RADIOISOTOPES
400702* - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials