Effect of ovariectomy and 17 beta-estradiol implantation on bone metabolism in female rats fed 1,25 dihydroxyvitamin D/sub 3/

Conference · Sat Mar 01 00:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:5450405

Osborne, M; Sherman, S; Soares, Jr, J H

Eight-week old Sprague-Dawley female rats were used in two experiments to test the effects of 17-B estradiol (E/sub 2/) via silastic tubing implants on /sup 3/H-labelled tetracycline (TC) incorporation into bone. 1,25(OH)/sub 2/D/sub 3/ was the dietary source of vitamin D in a low calcium (.2%) semipurified eggwhite diet. In experiment I, the Ovx + E/sub 2/ animals showed a significantly (p < .01) higher /sup 3/H TC uptake in scapula during a 2-week labelling experiment. An increase in /sup 3/H TC content resulted (p < .01) when E/sub 2/ was implanted in 1,25(OH)/sub 2/D/sub 3/ fed Ovx rats. However, the calcium content was not significantly different. The effect of dietary 1,25(OH)/sub 2/D/sub 3/ and E/sub 2/ implantation appears to be additive. Optimal action of the Vitamin D endocrine system may be dependent on presence of E/sub 2/.

• Research Organization: Univ. of Maryland, College Park
• OSTI ID: 5450405
• Report Number(s): CONF-8604222-; TRN: 86-028405
• Journal Information: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:3; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ESTRADIOL
BIOLOGICAL EFFECTS
IMPLANTS
SURGERY
VITAMIN D
METABOLISM
OVARIES
RATS
SKELETON
TETRACYCLINES
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
BODY
DRUGS
ESTRANES
ESTROGENS
FEMALE GENITALS
GONADS
HORMONES
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MEDICINE
ORGANIC COMPOUNDS
ORGANS
RODENTS
STEROID HORMONES
STEROIDS
VERTEBRATES
VITAMINS
550501* - Metabolism- Tracer Techniques