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Title: Particle shedding and migration from silicone genitourinary prosthetic devices

Abstract

Of 26 patients undergoing revision of genitourinary prostheses the surrounding reactive fibrous capsule was biopsied in 25 and the draining lymph nodes also were biopsied in 4. The prostheses included 16 inflatable and 14 flexible penile devices, and 10 artificial urinary sphincters. Tissue was examined by light and transmission electron microscopy. X-ray microanalysis was done on intracellular and extracellular foreign material from each specimen. Silicone was found in 18 of the 25 periprosthetic specimens and in all 4 lymph nodes. Foreign body granulomas were identified in 14 of these 29 specimens. Examination of new and explanted versions of each prosthesis by scanning electron microscopy revealed free particles of silicone or silicates on the surface of most devices. Pitting and microfissuring were seen on a few of the new devices and on nearly all of the used ones. Thus, genitourinary prostheses shed silicone particles that can be found in the fibrous capsule and draining lymph nodes.

Authors:
; ; ; ;  [1]
  1. Department of Urology, Mayo Clinic, Rochester, MN (USA)
Publication Date:
OSTI Identifier:
5449929
Resource Type:
Journal Article
Journal Name:
Journal of Urology; (United States)
Additional Journal Information:
Journal Volume: 146:2; Journal ID: ISSN 0022-5347
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ANIMAL TISSUES; ELECTRON MICROPROBE ANALYSIS; URINARY TRACT; PROSTHESES; BIOPSY; FIBROSIS; GRANULOMAS; LYMPH NODES; PATIENTS; SCANNING ELECTRON MICROSCOPY; SILICONES; TRANSMISSION ELECTRON MICROSCOPY; BODY; CHEMICAL ANALYSIS; DIAGNOSTIC TECHNIQUES; DISEASES; ELECTRON MICROSCOPY; LYMPHATIC SYSTEM; MEDICAL SUPPLIES; MICROANALYSIS; MICROSCOPY; NEOPLASMS; NONDESTRUCTIVE ANALYSIS; ORGANIC COMPOUNDS; ORGANIC SILICON COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; POLYMERS; SILOXANES; TISSUES; 550602* - Medicine- External Radiation in Diagnostics- (1980-)

Citation Formats

Barrett, D M, O'Sullivan, D C, Malizia, A A, Reiman, H M, and Abell-Aleff, P C. Particle shedding and migration from silicone genitourinary prosthetic devices. United States: N. p., 1991. Web.
Barrett, D M, O'Sullivan, D C, Malizia, A A, Reiman, H M, & Abell-Aleff, P C. Particle shedding and migration from silicone genitourinary prosthetic devices. United States.
Barrett, D M, O'Sullivan, D C, Malizia, A A, Reiman, H M, and Abell-Aleff, P C. 1991. "Particle shedding and migration from silicone genitourinary prosthetic devices". United States.
@article{osti_5449929,
title = {Particle shedding and migration from silicone genitourinary prosthetic devices},
author = {Barrett, D M and O'Sullivan, D C and Malizia, A A and Reiman, H M and Abell-Aleff, P C},
abstractNote = {Of 26 patients undergoing revision of genitourinary prostheses the surrounding reactive fibrous capsule was biopsied in 25 and the draining lymph nodes also were biopsied in 4. The prostheses included 16 inflatable and 14 flexible penile devices, and 10 artificial urinary sphincters. Tissue was examined by light and transmission electron microscopy. X-ray microanalysis was done on intracellular and extracellular foreign material from each specimen. Silicone was found in 18 of the 25 periprosthetic specimens and in all 4 lymph nodes. Foreign body granulomas were identified in 14 of these 29 specimens. Examination of new and explanted versions of each prosthesis by scanning electron microscopy revealed free particles of silicone or silicates on the surface of most devices. Pitting and microfissuring were seen on a few of the new devices and on nearly all of the used ones. Thus, genitourinary prostheses shed silicone particles that can be found in the fibrous capsule and draining lymph nodes.},
doi = {},
url = {https://www.osti.gov/biblio/5449929}, journal = {Journal of Urology; (United States)},
issn = {0022-5347},
number = ,
volume = 146:2,
place = {United States},
year = {Thu Aug 01 00:00:00 EDT 1991},
month = {Thu Aug 01 00:00:00 EDT 1991}
}