Labeled factor IX kinetics in patients with hemophilia-B

Journal Article · Tue Sep 01 00:00:00 EDT 1981 · Blood; (United States)

OSTI ID:5449383

Smith, K J; Thompson, A R

Labeled factor IX was infused five time into four patients with hemophilia-B. Ten-minute plasma recovery average 35% (SD +/- 2) and the mean T 1/2 beta-phase elimination was 23 hr (+/- 5). No alteration in the postinfusion 125I-factor-IX could be detected by radioautography of plasma samples run on polyacrylamide gels or on crossed-immunoelectrophoresis. Label was excreted into the urine as free 125I-iodide. Kinetics were similar when the labeled preparation was infused alone or with a commercial concentrate containing unlabeled factor IX. Infusion of factor IX in man is best described by a two-compartment open pharmacokinetic model where factor IX is distributed in a space larger than the plasma volume.

• OSTI ID: 5449383
• Journal Information: Blood; (United States), Vol. 58:3
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BLOOD CHEMISTRY
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HEMIC DISEASES
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IODINE 125
RADIONUCLIDE KINETICS
TRACER TECHNIQUES
AUTORADIOGRAPHY
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BIOLOGICAL MATERIALS
BLOOD
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INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
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NUCLEI
ODD-EVEN NUCLEI
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550901* - Pathology- Tracer Techniques
550601 - Medicine- Unsealed Radionuclides in Diagnostics
551001 - Physiological Systems- Tracer Techniques