Prostaglandin content of tissue lining vascular prostheses

Conference · Sat Mar 01 00:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:5448585

Greisler, H P; Kim, D U; Nussbaum, M; Ellinger, J; Schwarcz, T H

This laboratory previously demonstrated arterial regeneration with a confluent endothelial-like flow surface 3-4 weeks after interposition of absorbable prostheses but not of dacron prostheses into the rabbit aorta. This study evaluates prostaglandin contents of inner capsular tissues within arterial prostheses. 6-keto-PGF/sub 1..cap alpha../ and TxB/sub 2/ were assayed (/sup 3/H-RIA) in supernatants of sonicated homogenates of tissues on the inner aspect of (a) absorbable polydioxanone (PDS), (b) absorbable polyglactin 910 (PG910), or (c) compound dacron-PG910 prostheses 3 or 6 months following implantation into rabbit aortas. Normal aortic controls from each rabbit were similarly treated. The 6-keto-PGF/sub 1..cap alpha../ values for all groups were lower than normal controls (p < .05). The ratio 6-keto-PGF/sub 1..cap alpha..//TxB/sub 2/ for PDS was nearly identical to normal aorta (1.69 +/- .54). This study shows that the quantity and ratio of eicosanoids in the inner capsular tissues is modified by the composition of the implanted arterial prosthesis.

• Research Organization: Loyola Univ. Medical Center, Chicago, IL
• OSTI ID: 5448585
• Report Number(s): CONF-8604222-; TRN: 86-028523
• Journal Information: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:3; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
AORTA
BIOLOGICAL REGENERATION
IMPLANTS
PROSTAGLANDINS
CHEMICAL COMPOSITION
EICOSANOIC ACID
RABBITS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ANIMALS
ARTERIES
BIOLOGICAL RECOVERY
BLOOD VESSELS
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RECOVERY
VERTEBRATES
550901* - Pathology- Tracer Techniques