Effects of split-dose X irradiation on rat salivary gland function
- Department of Radiobiology, University of Groningen (Netherlands)
The effect of a single local dose of 15 Gy on salivary gland function in male Albino Wistar rats was compared with the effect of two doses of 7.5 Gy. The intervals chosen were 0-24 h and 1 week. Before and 1-30 days after the last radiation dose, samples of parotid and submandibular saliva were collected simultaneously after stimulation of the glands with pilocarpine. Irradiation with the single dose resulted in an increased lag phase and potassium concentration, and a decreased flow rate and sodium concentration. The rate of secretion of amylase was decreased during Days 1-6, increased at Day 10, and was decreased again at Day 30. With two dose fractions, substantial dose-sparing effects on lag phase, flow rate, and secretion of amylase were observed for both the very early (0-6 days postirradiation) and later (6-30 days postirradiation) effects. These effects were maximal when the interval between the fractions was 6 h. A significant dose-sparing effect on electrolytes was observed for the later effects only, again with a maximum for the 6-h interval. The dose-sparing observed for the very early effects cannot be explained satisfactorily by repair of sublethal damage (SLD), redistribution of cells over the cell cycle, or repopulation of salivary gland tissue between the doses. In contrast to the earlier dose-sparing effects, the split-dose recovery seen for later damage may be attributed, in part, to SLD repair in providing for greater reproductive survival of intercalated ductal cells and enhanced tissue regeneration.
- OSTI ID:
- 5448366
- Journal Information:
- Radiation Research; (United States), Vol. 127:1; ISSN 0033-7587
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
SALIVARY GLANDS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL REPAIR
CELL CYCLE
FLOW RATE
FRACTIONATED IRRADIATION
POTASSIUM
RADIATION DOSES
RATS
SALIVA
SODIUM
X RADIATION
ALKALI METALS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RECOVERY
BODY
BODY FLUIDS
DOSES
ELECTROMAGNETIC RADIATION
ELEMENTS
GLANDS
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MATERIALS
METALS
ORGANS
RADIATION EFFECTS
RADIATIONS
RECOVERY
REPAIR
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals