Murine cytomegalovirus stimulates natural killer cell function but kills genetically resistant mice treated with radioactive strontium
Treatment of C3H/St mice with 100 microCi of 89Sr weakened their genetic resistance to murine cytomegalovirus (MCMV) infection. The criteria utilized to detect increased susceptibility were: (i) survival of mice; (ii) numbers of MCMV-infected cells in the spleens and liver; and (iii) serum glutamic pyruvic transaminase levels. The natural killer (NK) cell activity of spleen cells from mice treated with 89Sr is very low. However, the NK activities of spleen cells of both normal and 89Sr-treated mice were greatly augmented 3 days after infection with MCMV. These NK cells lysed a variety of tumor cells and shared several features with conventional NK cells, but were not lysed by anti-Nk-1.2 serum (specific for NK cells) plus complement. Splenic adherent cells did not lyse tumor cells themselves but were necessary for the stimulation of NK cells by MCMV. The paradox of high NK cell function and poor survival in 89Sr-treated mice infected with MCMV was a surprise. We conclude that these augmented NK cells, of themselves, cannot account for the genetic resistance of C3H/St mice to infection with MCMV.
- Research Organization:
- Department of Pathology, Boston University School of Medicine, Massachusetts
- OSTI ID:
- 5448125
- Journal Information:
- Infect. Immun.; (United States), Vol. 34:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
IMMUNE REACTIONS
GENETIC RADIATION EFFECTS
STRONTIUM 89
BIOLOGICAL RADIATION EFFECTS
VIRUSES
INFECTIVITY
GENETIC VARIABILITY
MICE
ALKALINE EARTH ISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL VARIABILITY
DAYS LIVING RADIOISOTOPES
EVEN-ODD NUCLEI
GENETIC EFFECTS
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
MICROORGANISMS
NUCLEI
PARASITES
RADIATION EFFECTS
RADIOISOTOPES
RODENTS
STRONTIUM ISOTOPES
VERTEBRATES
560162* - Radionuclide Effects
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Plants
Microorganisms
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560152 - Radiation Effects on Animals- Animals