Effect of chloramphenicol and ethidium bromide on the level of ornithine carbamoyltransferase in Neurospora crassa

Journal Article · Thu May 01 00:00:00 EDT 1986 · J. Bacteriol.; (United States)

OSTI ID:5447215

Zerez, C R; Weiss, R L

The specific activity of the nuclear-gene-encoded, mitochondrial arginine biosynthetic enzyme ornithine carbamoyltransferase in Neurospora crassa was elevated in mycelia treated with chloramphenicol or ethidium bromide. The increase in specific activity was caused by an increase in the number of mature enzyme molecules rather than by the activation of a preexisting enzyme. Chloramphenicol and ethidium bromide appeared to act indirectly via arginine-mediated derepression. However, derepression did not appear to result from a drug-mediated decrease in the arginine pool.

• Research Organization: Univ. of California, Los Angeles
• OSTI ID: 5447215
• Journal Information: J. Bacteriol.; (United States), Vol. 166:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BROMIDES
BIOLOGICAL EFFECTS
CHLORAMPHENICOL
TRANSFERASES
ENZYME ACTIVITY
MITOCHONDRIA
NEUROSPORA
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
BROMINE COMPOUNDS
CELL CONSTITUENTS
DRUGS
ENZYMES
FUNGI
HALIDES
HALOGEN COMPOUNDS
ORGANOIDS
PLANTS
560303* - Chemicals Metabolism & Toxicology- Plants- (-1987)