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Title: Plasma disappearance, urine excretion, and tissue distribution of ribavirin in rats and rhesus monkeys

Abstract

Ribavirin has been shown to have broad-spectrum antiviral. To study its tissue distribution and disappearance rate, a single dose of 10 mg/kg which contained 10 microCi of (14C)ribavirin was injected intravenously into rhesus monkeys and intramuscularly into monkeys and rats. Except for peak plasma concentrations and the initial phases of the plasma disappearance and urine excretion curves, no significant difference was observed between plasma, tissue, or urine values for intramuscularly or intravenously injected monkeys. Plasma disappearance curves were triphasic; plasma concentrations of ribavirin were similar for both monkeys and rats. Rats excreted ribavirin in the urine more rapidly and to a greater extent (82% excreted in 24 h) than did monkeys (60% excreted in 72 h). In the rat, only 3% of the injected (14C)ribavirin was detected in expired CO2. Therefore, for both species, urine was the major route for the elimination of labeled ribavirin and its metabolites from the body. In monkeys, the amount of parent drug in blood cells increased through 48 h and remained stable for 72 h, whereas in rats, ribavirin decreased at a rate similar to the plasma disappearance curve. Concentrations of ribavirin at 8 h were consistently higher in monkeys than in rats formore » all tissues except the brain. Thus, these differences in blood cellular components and organ content and in urine excretion suggested that there was greater tissue retention of ribavirin in monkeys than in rats.« less

Authors:
; ; ;
Publication Date:
OSTI Identifier:
5443512
Resource Type:
Journal Article
Journal Name:
Antimicrob. Agents Chemother.; (United States)
Additional Journal Information:
Journal Volume: 19:6
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; CARBON 14 COMPOUNDS; TRACER TECHNIQUES; DRUGS; METABOLISM; PHARMACOLOGY; BLOOD PLASMA; MACACUS; METABOLITES; RATS; RETENTION; TISSUE DISTRIBUTION; URINE; VIRUSES; ANIMALS; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BLOOD; BODY FLUIDS; DISTRIBUTION; ISOTOPE APPLICATIONS; LABELLED COMPOUNDS; MAMMALS; MATERIALS; MICROORGANISMS; MONKEYS; PARASITES; PRIMATES; RODENTS; VERTEBRATES; WASTES; 550201* - Biochemistry- Tracer Techniques; 550701 - Microbiology- Tracer Techniques

Citation Formats

Ferrara, E A, Oishi, J S, Wannemacher, Jr, R W, and Stephen, E L. Plasma disappearance, urine excretion, and tissue distribution of ribavirin in rats and rhesus monkeys. United States: N. p., 1981. Web. doi:10.1128/AAC.19.6.1042.
Ferrara, E A, Oishi, J S, Wannemacher, Jr, R W, & Stephen, E L. Plasma disappearance, urine excretion, and tissue distribution of ribavirin in rats and rhesus monkeys. United States. https://doi.org/10.1128/AAC.19.6.1042
Ferrara, E A, Oishi, J S, Wannemacher, Jr, R W, and Stephen, E L. 1981. "Plasma disappearance, urine excretion, and tissue distribution of ribavirin in rats and rhesus monkeys". United States. https://doi.org/10.1128/AAC.19.6.1042.
@article{osti_5443512,
title = {Plasma disappearance, urine excretion, and tissue distribution of ribavirin in rats and rhesus monkeys},
author = {Ferrara, E A and Oishi, J S and Wannemacher, Jr, R W and Stephen, E L},
abstractNote = {Ribavirin has been shown to have broad-spectrum antiviral. To study its tissue distribution and disappearance rate, a single dose of 10 mg/kg which contained 10 microCi of (14C)ribavirin was injected intravenously into rhesus monkeys and intramuscularly into monkeys and rats. Except for peak plasma concentrations and the initial phases of the plasma disappearance and urine excretion curves, no significant difference was observed between plasma, tissue, or urine values for intramuscularly or intravenously injected monkeys. Plasma disappearance curves were triphasic; plasma concentrations of ribavirin were similar for both monkeys and rats. Rats excreted ribavirin in the urine more rapidly and to a greater extent (82% excreted in 24 h) than did monkeys (60% excreted in 72 h). In the rat, only 3% of the injected (14C)ribavirin was detected in expired CO2. Therefore, for both species, urine was the major route for the elimination of labeled ribavirin and its metabolites from the body. In monkeys, the amount of parent drug in blood cells increased through 48 h and remained stable for 72 h, whereas in rats, ribavirin decreased at a rate similar to the plasma disappearance curve. Concentrations of ribavirin at 8 h were consistently higher in monkeys than in rats for all tissues except the brain. Thus, these differences in blood cellular components and organ content and in urine excretion suggested that there was greater tissue retention of ribavirin in monkeys than in rats.},
doi = {10.1128/AAC.19.6.1042},
url = {https://www.osti.gov/biblio/5443512}, journal = {Antimicrob. Agents Chemother.; (United States)},
number = ,
volume = 19:6,
place = {United States},
year = {Mon Jun 01 00:00:00 EDT 1981},
month = {Mon Jun 01 00:00:00 EDT 1981}
}