Quantifying local cerebral blood flow by N-isopropyl-p-(123I)iodoamphetamine (IMP) tomography

Journal Article · Mon Mar 01 00:00:00 EST 1982 · J. Nucl. Med.; (United States)

OSTI ID:5442107

Kuhl, D E; Barrio, J R; Huang, S C; Selin, C; Ackermann, R F; Lear, J L; Wu, J L; Lin, T H; Phelps, M E

A model was validated wherein local cerebral blood flow (LCBF) in humans was quantified by single-photon emission computed tomography (SPECT) with intravenously injected N-isopropyl-p-(123I)iodoamphetamine (IMP) combined with a modification of the classic method of arterial input sampling. After intravenous injection of IMP in rat, autoradiograms of the brain showed activity distributions in the pattern of LCBF. IMP was nearly completely removed on first pass through monkey brain after intracarotid injection (CBF.33 ml/100 g/min) and washed out with a half-time of approximately 1 hr. When the modified method of arterial input and tissue-sample counting applied to dog brain, there was good correspondence between LCBF based on IMP and on that by microsphere injection over a wide flow range. In applying the method to human subjects using SPECT, whole-brain CBF measured 47.2 +/- 5.4 ml/100 g/min (mean +/- s.d., N.5), stable gray-white distinction persisted for over 1 hr, and the half-time for brain washout was approximately 1 hr. Perfusion deficits in patients were clearly demonstrated and quantified, comparing well with results now available from positron ECT.

• Research Organization: Laboratory of Nuclear Medicine, UCLA School of Medicine, Los Angeles, CA
• OSTI ID: 5442107
• Journal Information: J. Nucl. Med.; (United States), Vol. 23:3
• Country of Publication: United States
• Language: English

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550602* - Medicine- External Radiation in Diagnostics- (1980-)