Whole bone marrow irradiation for the treatment of multiple myeloma

Journal Article · Thu Apr 01 00:00:00 EST 1982 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19820401)49:7<1328::AID-CNCR2820490703>3.0.CO;2-4· OSTI ID:5441957

Coleman, M; Saletan, S; Wolf, D; Nisce, L; Wasser, J; McIntyre, O R; Tulloh, M

Nine patients with multiple myeloma were treated with whole bone marrow irradiation. Six had heavily pretreated disease refractory to chemotherapy. Three had stable disease lightly pretreated by chemotherapy. A modification of the ''three and two'' total nodal radiation technique was employed. Although varying and often severe treatment related cytopenia occurred, infectious complications, clinical bleeding, and nonhematalogic complications were minimal. Five of nine patients showed a decrease in monoclonal protein components, and one showed an increase during treatment. These preliminary results indicate that a reduction of tumor cell burden may occur in patients following whole bone marrow irradiation and that the technique is feasible. Whole bone marrow irradiation combined with chemotherapy represents a new conceptual therapeutic approach for multiple myeloma.

• Research Organization: Cornell University Medical College, New York, NY
• OSTI ID: 5441957
• Journal Information: Cancer (Philadelphia); (United States), Vol. 49:7
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BONE MARROW
NEOPLASMS
RADIOTHERAPY
ADULTS
ELDERLY PEOPLE
FEMALES
IRRADIATION
PATIENTS
AGE GROUPS
ANIMAL TISSUES
BODY
DISEASES
HEMATOPOIETIC SYSTEM
HUMAN POPULATIONS
MEDICINE
MINORITY GROUPS
NUCLEAR MEDICINE
ORGANS
POPULATIONS
RADIOLOGY
THERAPY
TISSUES
550603* - Medicine- External Radiation in Therapy- (1980-)