The effects of irradiation on blood components

Journal Article · Thu Jan 01 00:00:00 EST 1981 · Transfusion (Philadelphia); (United States)

DOI:https://doi.org/10.1046/j.1537-2995.1981.21481275998.x· OSTI ID:5441600

Button, L N; DeWolf, W C; Newburger, P E; Jacobson, M S; Kevy, S V

The functional properties of formed elements of whole blood were studied following irradiation doses of 500 to 20,000 rads. Irradiated lymphocytes retained only 1.5 per cent of their 3H thymidine uptake after a 5,000-rad exposure and none after 7,500 rads. Red blood cells stored for 21 days and then irradiated with 5,000 rads had the same survival as nonirradiated controls. In contrast, 5,000 rads reduced platelet yields. However, transfused irradiated platelets produced the expected increases in platelet counts and controlled hemostasis in thrombocytopenic patients. After 5,000 rads, granulocytes had normal bacterial killing capacity, chemotactic mobility, and normal superoxide production after high-dose stimulation. Nitroblue tetrazolium reduction and ingestion stimulated by complement opsonized oil droplets were not diminished by 5,000- and 10,000-rad irradiation. The functional qualities of cellular blood components other than lymphocytes are not compromised by 5,000 rads. This irradiation dose may be an effective means of controlling incidence of graft-vs-host disease in immunosuppressed patients.

• OSTI ID: 5441600
• Journal Information: Transfusion (Philadelphia); (United States), Vol. 21:4
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BLOOD PLATELETS
BIOLOGICAL RADIATION EFFECTS
ERYTHROCYTES
LEUKOCYTES
LYMPHOCYTES
DOSE-RESPONSE RELATIONSHIPS
DYNAMIC FUNCTION STUDIES
EXTERNAL IRRADIATION
GRAFT-HOST REACTION
PATIENTS
RADIATION DOSES
THYMIDINE
TRITIUM COMPOUNDS
UPTAKE
ANIMAL CELLS
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DOSES
HETEROCYCLIC COMPOUNDS
IRRADIATION
LABELLED COMPOUNDS
MATERIALS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIMIDINES
RADIATION EFFECTS
RIBOSIDES
SOMATIC CELLS
550603* - Medicine- External Radiation in Therapy- (1980-)
560151 - Radiation Effects on Animals- Man