Metabolism of manganese, iron, copper, and selenium in calves
Sixteen male Holstein calves were used to study manganese and iron metabolism. The calves were fed one of the following diets for 18 days: control, control + iron, control + manganese, and control + iron and manganese. All calves were dosed orally with manganese-54. Tissue concentrations of manganese, iron and manganese-54 were determined. Small intestinal iron was lower in calves fed the high manganese diet than in controls. Tissue manganese-54 was lower in calves fed a high manganese diet. Fecal manganese content increased in calves fed both high manganese and high manganese-high iron diets. Serum total iron was not affected by the dietary treatments. To study the effects of high dietary levels of copper and selenium on the intracellular distributions of these two elements in liver and kidney cytosol, calves were fed one of four diets for 15 days. These were 0 and 100 ppM supplemental copper and 0 and 1 ppM added selenium. The control diet containing 0.1 ppM of selenium and 15 ppM of copper. All calves were orally dosed 48 hrs prior to sacrifice with selenium-75. A high copper diet increased copper concentrations in all intracellular liver fractions and most kidney fractions. Only the effects in the liver were significant. Less copper was found in the mitochondria fractions in liver and kidney of calves fed a high selenium diet. Three major copper-binding protein peaks were separated from the soluble fractions of calf liver and kidney. Peak 1 appeared to be the major copper-binding protein in liver and kidney cytosol of copper-loaded animals. Added selenium alone or in combination with copper accentuated the copper accumulation in this peak. Most of selenium-75 was recovered in the same peak as the copper. The results of this experiment indicated that the large molecular proteins in liver and kidney cytosol of calves play an important role in copper and selenium-75 metabolism. (ERB)
- OSTI ID:
- 5439783
- Resource Relation:
- Other Information: Thesis (Ph. D.)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
IRON
METABOLISM
MANGANESE
COPPER
TISSUE DISTRIBUTION
SELENIUM
CALVES
INGESTION
TRACER TECHNIQUES
IRON CARBONATES
MANGANESE 54
MANGANESE CARBONATES
COPPER CARBONATES
KIDNEYS
LIVER
MITOCHONDRIA
SELENITES
SELENIUM 75
SODIUM COMPOUNDS
ALKALI METAL COMPOUNDS
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CARBON COMPOUNDS
CARBONATES
CATTLE
CELL CONSTITUENTS
COPPER COMPOUNDS
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
DOMESTIC ANIMALS
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
GLANDS
INTAKE
INTERMEDIATE MASS NUCLEI
IRON COMPOUNDS
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MANGANESE COMPOUNDS
MANGANESE ISOTOPES
METALS
NUCLEI
ODD-ODD NUCLEI
ORGANOIDS
ORGANS
OXYGEN COMPOUNDS
RADIOISOTOPES
RUMINANTS
SELENIUM COMPOUNDS
SELENIUM ISOTOPES
SEMIMETALS
TRANSITION ELEMENT COMPOUNDS
TRANSITION ELEMENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550501 - Metabolism- Tracer Techniques
551001 - Physiological Systems- Tracer Techniques