Joint inflammation in mice induced by a MT4/sup +/ Lyt-2/sup -/ T cell clone: characteristics and the induction of flare-up reactions
Joint inflammations were induced in mice by cloned MT4/sup +/ Lyt-2/sup -/ T cells specific for methylated bovine serum albumin. This was done either by intra-articular or by i.v. administration of the cloned T cells, together with local injection of the antigen. Local rechallenge with methylated bovine serum albumin several weeks after waning of the joint inflammation caused a flare-up reaction. The inflammations were quantified by a /sup 99m/Tc-uptake method and examined histologically. The arthritis induced by the cloned T cells showed aspects of a delayed type hypersensitivity reaction characterized by an intense infiltrate which resembles the inflammation in the human rheumatoid joint. The data presented show that join inflammations can be induced by T cells only and that, after waning, an exposition to the original antigen can induce a flare-up reaction. The data suggest a central role of T cells in the induction and the exacerbations observed in rheumatiod arthritis.
- Research Organization:
- Erasmus Univ., Rotterdam, Netherlands
- OSTI ID:
- 5435654
- Journal Information:
- J. Immunol.; (United States), Vol. 139:10
- Country of Publication:
- United States
- Language:
- English
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BONE JOINTS
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ALBUMINS
ANTIGENS
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LYMPHOCYTES
MICE
PERTECHNETATES
TECHNETIUM 99
TECHNETIUM COMPOUNDS
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
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BIOLOGICAL MATERIALS
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BLOOD CELLS
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BODY FLUIDS
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COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
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LEUKOCYTES
MAMMALS
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NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PROTEINS
RADIOISOTOPE SCANNING
RADIOISOTOPES
REFRACTORY METAL COMPOUNDS
RODENTS
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SKELETON
SOMATIC CELLS
SYMPTOMS
TECHNETIUM ISOTOPES
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics