Outcome of treatment of 313 patients with T-1 (UICC) prostate cancer treated with external beam irradiation
Three hundred and thirteen patients with UICC T-1 N-0 M-0 prostate cancer were treated with external beam irradiation in 1973 and 1974 or in 1978, and their outcome determined 3-10 years after treatment. Survival over the first 5 years was comparable to that expected for a group of age matched normal males (77% vs. 81%), but during the second 5-year interval, there was a decrease in survival below that expected (51% vs 62%), a reflection of death in patients who developed metastasis as a first recurrence (18%). Overall, 72% of patients were free of any recurrence at 5 years and, 88% free of infield recurrence. The development of metastatic recurrence was significantly related to grade; at 5 years 87% of grade I, 79% of grade II and 69% of grade III patients were free of metastasis. There was a trend for increased local recurrence with increasing grade, but it was not statistically significant. There was a dose/response relation for complications, and radiation doses above 6500 cGy are associated with an increase in complication from 6% to 11% (p = .09). Complications requiring hospitalization for evaluation or management occurred in 30 (10%) of 313 patients. There were no deaths from complications and less than 2% of patients required surgical correction of complications. External beam radiation offers the patient with early prostate cancer a favorable opportunity for cure without the morbidity of impotence, incontinence, and occasional death experienced following LND and radical prostatectomy. Lymph node dissection does not seem necessary for most patients with T-1 prostate cancer as the positive yield in those with Grades I and II cancers is less than the complications of the procedure, and extensive involvement can be detected by non-invasive means. 29 references.
- Research Organization:
- Univ. of Pennsylvania/Fox Chase Cancer Center (USA)
- OSTI ID:
- 5433400
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 14:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
NEOPLASMS
RADIOTHERAPY
PROSTATE
DOSE-RESPONSE RELATIONSHIPS
METASTASES
PATIENTS
POST-IRRADIATION EXAMINATION
SURVIVAL CURVES
BODY
DISEASES
GLANDS
MALE GENITALS
MEDICINE
NUCLEAR MEDICINE
ORGANS
RADIOLOGY
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)