In vitro magnetic relaxation times of the ischemic and reperfused rabbit kidney: concise communication

Journal Article · Sun Jan 01 00:00:00 EST 1984 · J. Nucl. Med.; (United States)

DOI:https://doi.org/10.1016/0730-725X(84)90081-X· OSTI ID:5433001

Slutsky, R A; Andre, M P; Mattrey, R F; Brahme, F J

To assess the effects of renal ischemia and reperfusion on in vitro magnetic relaxation times (T/sub 1/ = magnetization recovery, T/sub 2/ = spin echo), we evaluated the spectroscopic characteristics of the renal cortex from 25 rabbits. Eight served as controls (Group 1), nine had one renal pedicle ligated for 1 hr (Group 2), and eight (Group 3) were occluded for 1 hr and reperfused for 30 min. For intraanimal comparison purposes, % H/sub 2/O content, T/sub 1/ (msec), and T/sub 2/ (msec) of the ischemic (reperfused) kidney were normalized to the values from the normal kidney within the same animal. Renal ischemia consistently increased water content, which was exaggerated by reperfusion. In association with ischemia, T/sub 1/ fell, and with reperfusion T/sub 1/ lengthened. T/sub 2/ increased with ischemia and declined from the peak ischemic effects with reperfusion.

• Research Organization: Univ. of California Medical Center, San Diego
• OSTI ID: 5433001
• Journal Information: J. Nucl. Med.; (United States), Vol. 25:1
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
ISCHEMIA
DIAGNOSIS
KIDNEYS
NUCLEAR MAGNETIC RESONANCE
RELAXATION TIME
NMR SPECTRA
PERFUSED ORGANS
RABBITS
SPIN ECHO
ANIMALS
BODY
CARDIOVASCULAR DISEASES
DISEASES
MAGNETIC RESONANCE
MAMMALS
ORGANS
RESONANCE
SPECTRA
VASCULAR DISEASES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550900 - Pathology