Radiation biology: the conceptual and practical impact on radiation therapy
Radiation biology has had an important impact on clinical radiation therapy by providing a rationale for implementation of new treatment strategies and for clinical concepts or practices thereby increasing their acceptance. The observed rather narrow range of D/sub 0/ and n values for mammalian cells contributed to successful trials of radiation treatment of several ''radiation-resistant'' tumors, e.g., carcinoma of prostate, color-rectum, and sarcoma of soft tissue. Attention of clinicians was forcibly directed to assessment of local results (local failure, treatment complications) and not merely survival at 5 years by the extensive literature of cell survival curves (in vivo and in vitro) and dose-response assays on normal and tumor tissues. Upon these same laboratory results a scientific rationale was developed for use of shrinking field technique, low dose for subclinical disease, and the combination of moderate dose radiation therapy and conservative surgery. The entire area of clinical research into altered dose fractionation schedules is based upon research on cell proliferation kinetics and repair of radiation damage. The understanding that the time for complete regression of tumor depends not only upon cell kill but also on the pattern of cell proliferation of the progeny of lethally irradiated cells and the abundance of stroma provided a basis for accepting patients with slowly responding tumors for treatment. There remains a wide field of need in research in this area as even today a large proportion of patients who die of cancer die with their cancer uncontrolled at the primary site.
- Research Organization:
- Harvard Medical School, Boston, MA
- OSTI ID:
- 5429571
- Journal Information:
- Radiat. Res.; (United States), Vol. 94:1
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CARCINOMAS
RADIOSENSITIVITY
RADIOTHERAPY
RADIOBIOLOGY
SARCOMAS
ANIMAL CELLS
BIOLOGICAL REPAIR
CELL PROLIFERATION
DOSE-RESPONSE RELATIONSHIPS
FRACTIONATED IRRADIATION
PATIENTS
SURVIVAL CURVES
SURVIVAL TIME
BIOLOGICAL RECOVERY
BIOLOGY
DISEASES
IRRADIATION
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
RADIOLOGY
RECOVERY
REPAIR
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)
560151 - Radiation Effects on Animals- Man