Decreased bone uptake of technetium-99m polyphosphate in thalassemia major

Valdez, V A; Jacobstein, J G

Title: Decreased bone uptake of technetium-99m polyphosphate in thalassemia major

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Abstract

Bone scans were performed with Tc-99m stannous polyphosphate on four patients with thalassemia major. Three of the scans show generalized decrease in skeletal uptake of the radiopharmaceutical, associated with renal enlargement and markedly increased renal radioactivity. The skeletal findings are consistent with the known bone abnormalities in thalassemia major, which are secondary to the extensive marrow hyperplasia and include loss of trabeculae and cortical thinning with consequent loss of bone mass. The increased renal uptake is probably due in part to the increased renal excretion (secondary to the poor bone uptake) and in part to the tubular dilatation and renal enlargement associated with thalassemia major. In addition, the presence of excessive amounts of iron in these patients may play a role in both the skeletal and renal findings.

Authors:: Valdez, V A; Jacobstein, J G

Publication Date:: Tue Jan 01 00:00:00 EST 1980

Research Org.:: New York Hospital-Cornell Medical Center, NY

OSTI Identifier:: 5422499

Resource Type:: Journal Article

Journal Name:: J. Nucl. Med.; (United States)

Additional Journal Information:: Journal Volume: 21:1

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; SKELETON; SCINTISCANNING; TECHNETIUM 99; DIAGNOSTIC USES; THALASSEMIA; DIAGNOSIS; BIOLOGICAL LOCALIZATION; IRON; ISOMERIC NUCLEI; PATIENTS; RADIONUCLIDE KINETICS; RENAL CLEARANCE; RESPONSE MODIFYING FACTORS; UPTAKE; ANEMIAS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CLEARANCE; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DISEASES; ELEMENTS; EXCRETION; HEMIC DISEASES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; METALS; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPE SCANNING; RADIOISOTOPES; SYMPTOMS; TECHNETIUM ISOTOPES; TRANSITION ELEMENTS; USES; YEARS LIVING RADIOISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 560171 - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987)

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                    Valdez, V A, and Jacobstein, J G. Decreased bone uptake of technetium-99m polyphosphate in thalassemia major.  United States: N. p., 1980. 
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                    Valdez, V A, & Jacobstein, J G. Decreased bone uptake of technetium-99m polyphosphate in thalassemia major.  United States.

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                    Valdez, V A, and Jacobstein, J G. 1980.  
        "Decreased bone uptake of technetium-99m polyphosphate in thalassemia major".  United States.

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@article{osti_5422499,

  title        = {Decreased bone uptake of technetium-99m polyphosphate in thalassemia major},

  author       = {Valdez, V A and Jacobstein, J G},

  abstractNote = {Bone scans were performed with Tc-99m stannous polyphosphate on four patients with thalassemia major. Three of the scans show generalized decrease in skeletal uptake of the radiopharmaceutical, associated with renal enlargement and markedly increased renal radioactivity. The skeletal findings are consistent with the known bone abnormalities in thalassemia major, which are secondary to the extensive marrow hyperplasia and include loss of trabeculae and cortical thinning with consequent loss of bone mass. The increased renal uptake is probably due in part to the increased renal excretion (secondary to the poor bone uptake) and in part to the tubular dilatation and renal enlargement associated with thalassemia major. In addition, the presence of excessive amounts of iron in these patients may play a role in both the skeletal and renal findings.},

  doi          = {},

  url          = {https://www.osti.gov/biblio/5422499},
  journal      = {J. Nucl. Med.; (United States)},
number       = ,

  volume       = 21:1,

  place        = {United States},

  year         = {Tue Jan 01 00:00:00 EST 1980},

  month        = {Tue Jan 01 00:00:00 EST 1980}

}

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