Adrenergic receptors on cerebral microvessels in control and Parkinsonian subjects

Journal Article · Mon Aug 12 00:00:00 EDT 1985 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(85)90465-5· OSTI ID:5416380

Cash, R; Lasbennes, F; Sercombe, R; Seylaz, J; Agid, Y

The binding of adrenergic ligands (/sup 3/H-prazosin, /sup 3/H-clonidine, /sup 3/H-dihydroalprenolol) was studied on a preparation of cerebral microvessels in the prefrontal cortex and putamen of control and Parkinsonian subjects. The adrenergic receptor density in microvessels of control patients was less than 0.5% and 3.3% respectively of the total binding. A significant decrease in the number of alpha-1 binding sites was observed on microvessels in the putamen of patients with Parkinson's disease. 22 references, 2 tables.

• Research Organization: Laboratoire de Medecine Experimentale, Paris, France
• OSTI ID: 5416380
• Journal Information: Life Sci.; (United States), Vol. 37:6
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
SYMPATHOMIMETICS
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BRAIN
CHEMICAL BONDS
LIGANDS
NERVOUS SYSTEM DISEASES
PATIENTS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
CENTRAL NERVOUS SYSTEM
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550201* - Biochemistry- Tracer Techniques