The role of chemicals and radiation in the etiology of cancer
In this volume, investigators consider the mechanisms of oncogenesis, cell transformation, and carcinogen metabolism and present new findings on chemical and radiation carcinogenesis and chemically induced mutagenesis and chromosomal changes. As background to the studies of chemical and radiation carcinogenesis, the book surveys knowledge of cell transformation and carcinogen metabolism. Among the topics reviewed are the transforming genes involved in human malignancy, the genetics and epigenetics of neoplasia, and the single-hit and multi-hit concepts of hepatocarcinogenesis. Also examined are organ, species, and interindividual differences in carcinogen metabolism; chemical and biochemical dosimetry of genotoxic chemical exposure; and the role of pharmacokinetics and DNA dosimetry in relating in vitro to in vivo actions of N-nitroso compounds.
- OSTI ID:
- 5415319
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
NITROSO COMPOUNDS
CARCINOGENESIS
MUTAGENESIS
ONCOGENIC TRANSFORMATIONS
BIOCHEMISTRY
ANIMAL CELLS
CHROMOSOMAL ABERRATIONS
COMPARATIVE EVALUATIONS
DOSE-RESPONSE RELATIONSHIPS
DOSIMETRY
GENETIC RADIATION EFFECTS
METABOLISM
ONCOGENES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL TRANSFORMATIONS
CHEMISTRY
GENES
GENETIC EFFECTS
MUTATIONS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOGENESIS
RADIATION EFFECTS
560154* - Radiation Effects on Animals- Basic Studies- (-1987)
560306 - Chemicals Metabolism & Toxicology- Man- (-1987)