Correlation of stress with outcome of radioiodine therapy for Graves disease

Journal Article · Sat Jun 01 00:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:5414994

Stewart, T; Rochon, J; Lenfestey, R; Wise, P

Between November 1965 and December 1983, 293 patients were treated for Graves disease using /sup 131/I. All patients were asked to identify a stressful event antedating the onset of overt clinical symptoms. Eighty-one patients were able to do this (27.6%). Two hundred forty-four patients received a single treatment, 49 required two or more treatments. Patients with stress initiating the symptoms of Graves disease became hypothyroid earlier, 50% at 12 mo compared with 36 mo for the nonstress group. At 10 yr 5% of the stress group remained euthyroid compared with 17% nonstress. The authors conclude that stress in the 12 mo or less before the onset of clinical symptoms potentiates the development of hypothyroidism induced by a standard dose of radioiodine.

• Research Organization: Ottawa General Hospital, Ontario
• OSTI ID: 5414994
• Journal Information: J. Nucl. Med.; (United States), Vol. 26:6
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
BIOLOGICAL STRESS
BIOLOGICAL EFFECTS
RADIOTHERAPY
SIDE EFFECTS
THYROID
BIOLOGICAL RADIATION EFFECTS
HYPERTHYROIDISM
HYPOTHYROIDISM
IODINE 131
PATIENTS
RADIOSENSITIVITY EFFECTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIATION EFFECTS
RADIOISOTOPES
RADIOLOGY
THERAPY
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