Effects of diethyldithiocarbamate and selected analogs on cadmium metabolism following chronic cadmium ingestion
Effects of ip treatment with diethyldithiocarbamate (DDTC), 4- carboxamidopiperidine-N-dithiocarboxylate (CAP-N-DTC), and N-methyl-N- dithiocarboxyglucamine (MDCG) on cadmium (Cd) levels in selected mouse organs and tissues were assessed after mice were offered deionized water containing 0.05 mg/ml of CdCl/sub 2/ x 2.5 H/sub 2/O, 10 mg/ml of sucrose, and 0.125 microCi/ml of carrier-free /sup 109/CdCl/sub 2/ as the sole drinking fluid for 15 days. Only 0.31 +/- 0.01 % of the ingested Cd was absorbed. Data obtained following treatment were compared with those obtained earlier in similar studies following ip Cd injection. In contrast to its action when administered after ip Cd injection, DDTC enhanced hepatic Cd burdens in mice which received Cd po. DDTC did, however, reduce renal Cd levels markedly after Cd ingestion, while enhancing brain Cd levels. CAP- N-DTC and MDCG, which were shown earlier to have no effect on Cd levels in striated muscle following ip Cd administration, effected significant reduction of muscle Cd concentrations after Cd administration po, while also reducing hepatic and renal Cd levels significantly. It was concluded that certain dithiocarbamates effectively mobilize and promote excretion of Cd which has been absorbed from one of the natural portals of entry.
- Research Organization:
- Veterans Administration Medical Center, Charleston, SC
- OSTI ID:
- 5414404
- Journal Information:
- Res. Commun. Chem. Pathol. Pharmacol.; (United States), Vol. 47:1
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
CADMIUM
RETENTION
TISSUE DISTRIBUTION
CHELATING AGENTS
BIOLOGICAL EFFECTS
BRAIN
CADMIUM 109
CADMIUM CHLORIDES
EXCRETION
INGESTION
INTRAPERITONEAL INJECTION
KIDNEYS
LIVER
MICE
TRACER TECHNIQUES
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CADMIUM COMPOUNDS
CADMIUM HALIDES
CADMIUM ISOTOPES
CENTRAL NERVOUS SYSTEM
CHLORIDES
CHLORINE COMPOUNDS
CLEARANCE
DIGESTIVE SYSTEM
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
GLANDS
HALIDES
HALOGEN COMPOUNDS
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
METALS
NERVOUS SYSTEM
NUCLEI
ORGANS
RADIOISOTOPES
RODENTS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550501 - Metabolism- Tracer Techniques