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Title: Lack of effect of spinal anesthesia on drug metabolism

Abstract

The effect of spinal anesthesia on drug disposition was determined in six dogs with chronically implanted vascular catheters using propranolol as a model compound. On the first study day, 40 mg of unlabeled propranolol and 200 microCi of (3H)propranolol were injected into the portal and femoral veins respectively. Arterial blood samples were taken for 4 hr for measurement of plasma concentrations of labeled and unlabeled propranolol by high-pressure liquid chromatography (HPLC) and of (3H)propranolol by liquid scintillation counting of the HPLC eluant corresponding to each propranolol peak. Twenty-four hr later, spinal anesthesia was induced with tetracaine (mean dose 20.7 +/- 0.6 mg) with low sacral to midthoracic levels and the propranolol infusions and sampling were then repeated. Spinal anesthesia had no significant effect on either the intrinsic clearance of propranolol (2.01 +/- 0.75 L/min before and 1.9 +/- 0.7 L/min during spinal anesthesia), or on mean hepatic plasma flow (2.01 +/- 0.5 L/min before and 1.93 +/- 0.5 L/min during spinal anesthesia). The systemic clearance and elimination half-life of propranolol were also unchanged by spinal anesthesia (0.9 +/- 0.23 L/min on the first day, 0.7 +/- 0.1 L/min during spinal anesthesia; and 101 +/- 21 min on the first day,more » 115 +/- 16 min during spinal anesthesia, respectively). The volume of distribution (Vd) of propranolol was similarly unaffected by spinal anesthesia.« less

Authors:
; ; ;  [1]
  1. Vanderbilt Univ. School of Medicine, Nashville, TN (USA)
Publication Date:
OSTI Identifier:
5412892
Resource Type:
Journal Article
Journal Name:
Anesthesia and Analgesia (Cleveland) (Current Researches); (USA)
Additional Journal Information:
Journal Volume: 69:3; Journal ID: ISSN 0003-2999
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; ANESTHESIA; BIOLOGICAL EFFECTS; SYMPATHOLYTICS; METABOLISM; DOGS; LIQUID COLUMN CHROMATOGRAPHY; LIVER; SCINTILLATION COUNTING; SPINAL CORD; TRACER TECHNIQUES; TRITIUM COMPOUNDS; ANIMALS; AUTONOMIC NERVOUS SYSTEM AGENTS; BODY; CENTRAL NERVOUS SYSTEM; CHROMATOGRAPHY; COUNTING TECHNIQUES; DIGESTIVE SYSTEM; DRUGS; GLANDS; HYDROGEN COMPOUNDS; ISOTOPE APPLICATIONS; MAMMALS; NERVOUS SYSTEM; ORGANS; SEPARATION PROCESSES; VERTEBRATES; 550201* - Biochemistry- Tracer Techniques

Citation Formats

Whelan, E, Wood, A J, Shay, S, and Wood, M. Lack of effect of spinal anesthesia on drug metabolism. United States: N. p., 1989. Web. doi:10.1213/00000539-198909000-00006.
Whelan, E, Wood, A J, Shay, S, & Wood, M. Lack of effect of spinal anesthesia on drug metabolism. United States. https://doi.org/10.1213/00000539-198909000-00006
Whelan, E, Wood, A J, Shay, S, and Wood, M. 1989. "Lack of effect of spinal anesthesia on drug metabolism". United States. https://doi.org/10.1213/00000539-198909000-00006.
@article{osti_5412892,
title = {Lack of effect of spinal anesthesia on drug metabolism},
author = {Whelan, E and Wood, A J and Shay, S and Wood, M},
abstractNote = {The effect of spinal anesthesia on drug disposition was determined in six dogs with chronically implanted vascular catheters using propranolol as a model compound. On the first study day, 40 mg of unlabeled propranolol and 200 microCi of (3H)propranolol were injected into the portal and femoral veins respectively. Arterial blood samples were taken for 4 hr for measurement of plasma concentrations of labeled and unlabeled propranolol by high-pressure liquid chromatography (HPLC) and of (3H)propranolol by liquid scintillation counting of the HPLC eluant corresponding to each propranolol peak. Twenty-four hr later, spinal anesthesia was induced with tetracaine (mean dose 20.7 +/- 0.6 mg) with low sacral to midthoracic levels and the propranolol infusions and sampling were then repeated. Spinal anesthesia had no significant effect on either the intrinsic clearance of propranolol (2.01 +/- 0.75 L/min before and 1.9 +/- 0.7 L/min during spinal anesthesia), or on mean hepatic plasma flow (2.01 +/- 0.5 L/min before and 1.93 +/- 0.5 L/min during spinal anesthesia). The systemic clearance and elimination half-life of propranolol were also unchanged by spinal anesthesia (0.9 +/- 0.23 L/min on the first day, 0.7 +/- 0.1 L/min during spinal anesthesia; and 101 +/- 21 min on the first day, 115 +/- 16 min during spinal anesthesia, respectively). The volume of distribution (Vd) of propranolol was similarly unaffected by spinal anesthesia.},
doi = {10.1213/00000539-198909000-00006},
url = {https://www.osti.gov/biblio/5412892}, journal = {Anesthesia and Analgesia (Cleveland) (Current Researches); (USA)},
issn = {0003-2999},
number = ,
volume = 69:3,
place = {United States},
year = {Fri Sep 01 00:00:00 EDT 1989},
month = {Fri Sep 01 00:00:00 EDT 1989}
}