Effect of cigarette smoke, nicotine, and carbon monoxide on the permeability of the arterial wall
The association between cigarette smoking and the development of atherosclerosis is well established, but the mechanism that makes cigarettes such a potent risk factor is not understood. There is normally a constant insudation of plasma macromolecules into the arterial wall. Fibrinogen and lipids are two of the large molecules involved in atherosclerosis. Therefore, we studied the effect of cigarette smoke, nicotine, and carbon monoxide on the permeability of the canine arterial wall to /sup 125/I-labeled fibrinogen. The results show that inhaled cigarette smoke significantly and rapidly increases the permeability of the arterial wall to fibrinogen and that this effect can be produced with carbon monoxide alone but not with intravenous nicotine.
- Research Organization:
- St. Thomas Hospital, London, England
- OSTI ID:
- 5405532
- Journal Information:
- J. Vasc. Surg.; (United States), Vol. 7:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
ARTERIES
PERMEABILITY
ARTERIOSCLEROSIS
EPIDEMIOLOGY
CARBON MONOXIDE
BIOLOGICAL EFFECTS
NICOTINE
TOBACCO SMOKES
CELL WALL
DOGS
FIBRINOGEN
IODINE 125
RISK ASSESSMENT
TRACER TECHNIQUES
AEROSOLS
ALKALOIDS
AMINES
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZINES
AZOLES
BETA DECAY RADIOISOTOPES
BLOOD COAGULATION FACTORS
BLOOD VESSELS
BODY
CARBON COMPOUNDS
CARBON OXIDES
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CELL CONSTITUENTS
CHALCOGENIDES
COAGULANTS
COLLOIDS
DAYS LIVING RADIOISOTOPES
DISEASES
DISPERSIONS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GLOBULINS
HEMATOLOGIC AGENTS
HEMOSTATICS
HETEROCYCLIC COMPOUNDS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PARASYMPATHOLYTICS
PARASYMPATHOMIMETICS
PROTEINS
PYRIDINES
PYRROLES
PYRROLIDINES
RADIOISOTOPES
RESIDUES
SMOKES
SOLS
VASCULAR DISEASES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
550501 - Metabolism- Tracer Techniques