Effects of arsenic trioxide inhalation exposure on pulmonary antibacterial defenses in mice

Journal Article · Tue Jan 01 00:00:00 EST 1985 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398509530643· OSTI ID:5405183

Aranyi, C; Bradof, J N; O'Shea, W J; Graham, J A; Miller, F J

The effects of single and multiple (5 and 20) 3-h inhalation exposures to aerosols of arsenic trioxide on the pulmonary defense system of mice were investigated. Arsenic trioxide mist was generated from an aqueous solution and dried to produce particulate aerosols of 0. 4 micron mass median aerodynamic diameter. Aerosol mass concentration ranged from 125 to 1000 micrograms As/m3. Effects of the exposures were evaluated by determination of changes in susceptibility to experimentally induced streptococcal aerosol infection and in pulmonary bactericidal activity to /sup 35/S-labeled Klebsiella pneumoniae. Significant increases in mortality due to the infectious challenge and decreases in bactericidal activity were seen after single 3-h exposures to 270, 500, and 940 micrograms As/m3. Similarly, 5 or 20 multiple 3-h exposures to 500 micrograms As/m3 produced consistently significant increases in mortality and decreases in pulmonary bactericidal activity. At 125 or 250 micrograms As/m3, a decrease in bactericidal activity was seen only after 20 exposures to 250 micrograms/m3. Results from earlier studies with an arsenic-containing copper smelter dust were compared to these data. The possibility of the development of adaptation during multiple exposures to arsenic trioxide is also considered.

• Research Organization: IIT Research Institute, Chicago, IL
• OSTI ID: 5405183
• Journal Information: J. Toxicol. Environ. Health; (United States), Vol. 15:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
AEROSOLS
TOXICITY
ARSENIC OXIDES
KLEBSIELLA
INFECTIVITY
STREPTOCOCCUS
IMMUNITY
INHALATION
LUNGS
MICE
MORTALITY
SULFUR 35
ANIMALS
ARSENIC COMPOUNDS
BACTERIA
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CHALCOGENIDES
COLLOIDS
DAYS LIVING RADIOISOTOPES
DISPERSIONS
EVEN-ODD NUCLEI
INTAKE
ISOTOPES
LIGHT NUCLEI
MAMMALS
MICROORGANISMS
NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
RADIOISOTOPES
RESPIRATORY SYSTEM
RODENTS
SOLS
SULFUR ISOTOPES
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
551001 - Physiological Systems- Tracer Techniques