Immunoscintigraphy with indium-111 labeled monoclonal antibodies: The importance of a good display method

Journal Article · Wed Mar 01 00:00:00 EST 1989 · Clinical Nuclear Medicine; (USA)

DOI:https://doi.org/10.1097/00003072-198903000-00010· OSTI ID:5403883

Liehn, J C; Hannequin, P; Nasca, S; Lebrun, D; Fernandez-Valoni, A; Valeyre, J ^[1]

---

1. Institut Jean Godinot, Reims (France)

A major drawback of In-111-labeled monoclonal antibodies (MoAb) is the presence of intense liver, renal, and bone marrow nonspecific activity. This makes the display of the images hardly optimal and their visual interpretation difficult. In this study, the intrinsic color scale (which consists of selecting the limits of the color scale as the highest and the lowest pixel value of the image) was compared to a new, simple algorithm for the determination of the limits of the color scale. This algorithm was based on the count density in the iliac crest areas. OC-125 or anti-CEA In-111 MoAb F(ab')2 fragments were used in 32 patients with suspected recurrence of ovarian (19 patients) or colorectal cancer (13 patients). Final diagnosis was assessed by surgery (21 patients), biopsy (five patients), or followup (six patients). A 10-minute abdomino-pelvic anterior view was recorded two days after injection. These views are displayed using the two methods and interpreted by two observers. Using their responses in each quadrant of the pelvis, the authors calculated two ROC curves. The comparison of the ROC curves showed better performances for the new method. For example, for the same specificity (73%), the sensitivity of the new method was significantly better (78% versus 68%). This result confirmed the importance of a good methodology for displaying immunoscintigraphic images.

• OSTI ID: 5403883
• Journal Information: Clinical Nuclear Medicine; (USA), Vol. 14:3; ISSN 0363-9762
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
LARGE INTESTINE
NEOPLASMS
MONOCLONAL ANTIBODIES
SPECIFICITY
DIAGNOSIS
OVARIES
RADIOIMMUNOSCINTIGRAPHY
SENSITIVITY ANALYSIS
RECTUM
ALGORITHMS
INDIUM 111
PATIENTS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BODY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
FEMALE GENITALS
GASTROINTESTINAL TRACT
GONADS
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
INTESTINES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MATHEMATICAL LOGIC
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOIMMUNODETECTION
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
TRACER TECHNIQUES
550601* - Medicine- Unsealed Radionuclides in Diagnostics