Gastrointestinal absorption of cadmium in mice during gestation and lactation

Journal Article · Fri Jan 01 00:00:00 EST 1982 · Toxicol. Appl. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0041-008X(82)90303-9· OSTI ID:5402490

Bhattacharyya, M H ^[1]; Whelton, B D; Peterson, D P

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1. Argonne National Lab., IL

The effect on cadmium retention of continuous exposure to drinking water containing low levels of cadmium during pregnancy and lactation was studied in mice. Female mice were provided drinking water ad libitum containing /sup 109/CdCl/sub 2/ (0.03 ..mu..Ci /sup 109/Cd/ml, 0.11 ppb total cadmium) throughout either gestation, lactation, or a combined period of pregnancy and lactation. Nonpregnant control mice were exposed to the same cadmium solution for similar time periods. Dams in all three experimental groups retained two to three times cadmium (expressed as percentage of ingested dose) than did nonpregnant controls. The /sup 109/Cd contents of liver, kidney, mammary tissue, and duodenum increased strikingly in all three groups. Increases in kidney and mammary tissue were particularly apparent during lactation, with increases of fivefold for kidney and at least ninefold for mammary tissue, compared to levels in nonpregnant controls. Increases in /sup 109/Cd retention by the duodenum were fivefold during gestation and three- to fourfold during lactation. The kidneys of dams exposed during lactation retained 53% of the whole body /sup 109/Cd, while kidneys of nonpregnant controls retained only 27%. Results indicate that pregnant and lactating mice absorb and subsequently retain substantially more cadmium from their diets than do nonpregnant mice.

• DOE Contract Number: W-31-109-ENG-38
• OSTI ID: 5402490
• Journal Information: Toxicol. Appl. Pharmacol.; (United States), Vol. 66
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
CADMIUM
INTESTINAL ABSORPTION
BIOLOGICAL ACCUMULATION
CADMIUM 109
CHRONIC INTAKE
DRINKING WATER
INGESTION
KIDNEYS
LABELLED COMPOUNDS
LACTATION
LIVER
MAMMARY GLANDS
MICE
PREGNANCY
RETENTION
SMALL INTESTINE
TRACER TECHNIQUES
ABSORPTION
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CADMIUM ISOTOPES
DIGESTIVE SYSTEM
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
GASTROINTESTINAL TRACT
GLANDS
HYDROGEN COMPOUNDS
INTAKE
INTERMEDIATE MASS NUCLEI
INTESTINES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
METALS
NUCLEI
ORGANS
OXYGEN COMPOUNDS
RADIOISOTOPES
RODENTS
UPTAKE
VERTEBRATES
WATER
YEARS LIVING RADIOISOTOPES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550501 - Metabolism- Tracer Techniques