Metabolic effects of fasting and very low calorie diets

Thesis/Dissertation · Wed Jan 01 00:00:00 EST 1986

OSTI ID:5401176

Henson, L C

To examine the mechanism of nitrogen sparing in obese subjects on very low calorie diets (VLC-PS), effects of total fasting (TF) and VLC-PS (380 Kcal/day) supplying protein without carbohydrate on metabolites, hormones, urea nitrogen excretion, and plasma (3-/sup 3/H)glucose turnover, (U-/sup 14/C)lysine flux, and (1-/sup 14/C)leucine flux and oxidation were compared. Subjects with a wide range of relative obesity were studied during a control period and after one week of TF. Urea excretion and lysine flux decreased in all subjects, while 3-methylhistidine excretion was unchanged. Glucagon:insulin ratio and cortisol increased, while triiodothyronine (T/sub 3/) decreased and would be expected to be nitrogen-sparing. In a separate study, groups of obese women were studied during a control period and during 14 days of TF or VLC-PS supplying either 80 g (80G) or 40 g (40G) high-quality protein. Increases in branched chain amino acids, ..beta..-hydroxybutyrate, and glucagon:insulin ratio and decrease in T/sub 3/ did not differ among groups. Glucose production decreased to the same extent in all groups. Serum and urinary urea nitrogen were maintained at control values throughout the diet in 80G but decreased to the same extent in TF and 40G. Nitrogen balance estimated from urea nitrogen appearance was negative in all groups.

• Research Organization: California Univ., Los Angeles (USA)
• OSTI ID: 5401176
• Resource Relation: Other Information: Thesis (Ph. D.)
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
FASTING
BIOLOGICAL EFFECTS
PHYSIOLOGY
CARBON 14 COMPOUNDS
DIET
GLUCOSE
LEUCINE
LYSINE
METABOLIC DISEASES
OXIDATION
TRACER TECHNIQUES
TRITIUM COMPOUNDS
WOMEN
ALDEHYDES
AMINO ACIDS
ANIMALS
CARBOHYDRATES
CARBOXYLIC ACIDS
CHEMICAL REACTIONS
DISEASES
FEMALES
HEXOSES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MAN
MONOSACCHARIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
PRIMATES
SACCHARIDES
VERTEBRATES
550501* - Metabolism- Tracer Techniques