One-electron reduction of adriamycin: properties of the semiquinone

Journal Article · Mon Aug 01 00:00:00 EDT 1983 · Arch. Biochem. Biophys.; (United States)

DOI:https://doi.org/10.1016/0003-9861(83)90013-9· OSTI ID:5398880

Land, E J; Mukherjee, T; Swallow, A J; Bruce, J M

Pulse radiolysis of aqueous solutions containing adriamycin and redox indicators of known one-electron reduction potential (E1) shows that its E1 at pH 7 is -328 mV (vs NHE). The variation E1 with pH in the range 6-12 shows that the net charge on the semiquinone at pH 7 is zero. As well as the pKa values of 2.9 and greater than or equal to 14 established independently, the semiquinone has a pKa close to 9.2. The new data enable the structure and likely reactivity of the semiquinone to be specified.

• Research Organization: Paterson Laboratories, Christie Hospital, England
• OSTI ID: 5398880
• Journal Information: Arch. Biochem. Biophys.; (United States), Vol. 225:1
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
DOXORUBICIN
CHEMICAL RADIATION EFFECTS
ELECTRIC POTENTIAL
ELECTROCHEMISTRY
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTINEOPLASTIC DRUGS
CHEMISTRY
DRUGS
RADIATION CHEMISTRY
RADIATION EFFECTS
400600* - Radiation Chemistry
400400 - Electrochemistry