Comparative kinetics of serum and vitreous humor digoxin concentrations in a guinea pig model. Part I: Intravenous administration of digoxin

Journal Article · Fri Mar 01 00:00:00 EST 1991 · Journal of Analytical Toxicology; (United States)

DOI:https://doi.org/10.1093/jat/15.2.60· OSTI ID:5398193

Donnelly, B; Balkon, J; Bidanset, J H; Belmonte, A; Barletta, M; Manning, T ^[1]

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1. Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St. John's University, Jamaica, NY (USA)

The pharmacokinetics of a single intravenous dose of digoxin in the guinea pig was investigated with emphasis on the penetration of digoxin into the vitreous humor. A controlled study was undertaken and data was collected which indicated that digoxin follows an open, two-compartment pharmacokinetic model with a terminal half-life of 318 minutes. The data indicated that the ratio of vitreous concentrations to serum concentrations were determined to be equal following an initial tissue distribution phase.

• OSTI ID: 5398193
• Journal Information: Journal of Analytical Toxicology; (United States), Vol. 15:2; ISSN 0146-4760
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DIGOXIN
TISSUE DISTRIBUTION
BIOLOGICAL HALF-LIFE
GUINEA PIGS
IODINE ISOTOPES
MATHEMATICAL MODELS
METABOLISM
REAGENTS
TRACER TECHNIQUES
ANIMALS
CARBOHYDRATES
CARDIAC GLYCOSIDES
CARDIOTONICS
CARDIOVASCULAR AGENTS
DIGITALIS GLYCOSIDES
DISTRIBUTION
DRUGS
GLYCOSIDES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
ORGANIC COMPOUNDS
RODENTS
VERTEBRATES
550501* - Metabolism- Tracer Techniques