The reproducibility of striatal uptake data obtained with positron emission tomography and fluorine-18-L-6-fluorodopa tracer in non-human primates

Pate, B D; Snow, B J; Hewitt, K A; Morrison, K S; Ruth, T J; Calne, D B

Title: The reproducibility of striatal uptake data obtained with positron emission tomography and fluorine-18-L-6-fluorodopa tracer in non-human primates

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Abstract

Cynomolgus and rhesus monkeys have been studied via PET with (18F)-L-6 fluorodopa tracer. Striatal fluorodopa uptake rate constants have been derived by graphical analysis of transaxial slice images centered on the striata. The differences between pairs of values of the rate constant, obtained from two scans on the same monkey separated by two weeks or more, exhibited a relative standard deviation of 34.4%. If the two scans were conducted one immediately after the other, with the position of the monkey undisturbed, the standard deviation was reduced to 14.0%. The utility of this technique was demonstrated by comparing the effects on the scans of halothane and pentobarbital anesthesia and by the administration of NSD 1015, a peripheral and central inhibitor of L-aromatic amino-acid decarboxylase, between back-to-back scans. With NSD 1015, the fluorodopa uptake constant was reduced by an average of 76.0%.

Authors:

Pate, B D; Snow, B J; Hewitt, K A; Morrison, K S; Ruth, T J; Calne, D B ^[1]

Department of Medicine, University of British Columbia, Vancouver (Canada)

Publication Date:: Sat Jun 01 00:00:00 EDT 1991

OSTI Identifier:: 5397725

Resource Type:: Journal Article

Journal Name:: Journal of Nuclear Medicine; (United States)

Additional Journal Information:: Journal Volume: 32:6; Journal ID: ISSN 0161-5505

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; RADIOPHARMACEUTICALS; UPTAKE; DOPA; FLUORINE 18; MONKEYS; POSITRON COMPUTED TOMOGRAPHY; AMINO ACIDS; ANIMALS; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; HYDROXY ACIDS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MAMMALS; NANOSEC LIVING RADIOISOTOPES; NEUROREGULATORS; NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; PRIMATES; RADIOISOTOPES; TOMOGRAPHY; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats


                    Pate, B D, Snow, B J, Hewitt, K A, Morrison, K S, Ruth, T J, and Calne, D B. The reproducibility of striatal uptake data obtained with positron emission tomography and fluorine-18-L-6-fluorodopa tracer in non-human primates.  United States: N. p., 1991. 
        Web.

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                    Pate, B D, Snow, B J, Hewitt, K A, Morrison, K S, Ruth, T J, & Calne, D B. The reproducibility of striatal uptake data obtained with positron emission tomography and fluorine-18-L-6-fluorodopa tracer in non-human primates.  United States.

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                    Pate, B D, Snow, B J, Hewitt, K A, Morrison, K S, Ruth, T J, and Calne, D B. 1991.  
        "The reproducibility of striatal uptake data obtained with positron emission tomography and fluorine-18-L-6-fluorodopa tracer in non-human primates".  United States.

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@article{osti_5397725,

  title        = {The reproducibility of striatal uptake data obtained with positron emission tomography and fluorine-18-L-6-fluorodopa tracer in non-human primates},

  author       = {Pate, B D and Snow, B J and Hewitt, K A and Morrison, K S and Ruth, T J and Calne, D B},

  abstractNote = {Cynomolgus and rhesus monkeys have been studied via PET with (18F)-L-6 fluorodopa tracer. Striatal fluorodopa uptake rate constants have been derived by graphical analysis of transaxial slice images centered on the striata. The differences between pairs of values of the rate constant, obtained from two scans on the same monkey separated by two weeks or more, exhibited a relative standard deviation of 34.4%. If the two scans were conducted one immediately after the other, with the position of the monkey undisturbed, the standard deviation was reduced to 14.0%. The utility of this technique was demonstrated by comparing the effects on the scans of halothane and pentobarbital anesthesia and by the administration of NSD 1015, a peripheral and central inhibitor of L-aromatic amino-acid decarboxylase, between back-to-back scans. With NSD 1015, the fluorodopa uptake constant was reduced by an average of 76.0%.},

  doi          = {},

  url          = {https://www.osti.gov/biblio/5397725},
  journal      = {Journal of Nuclear Medicine; (United States)},

  issn         = {0161-5505},

  number       = ,

  volume       = 32:6,

  place        = {United States},

  year         = {Sat Jun 01 00:00:00 EDT 1991},

  month        = {Sat Jun 01 00:00:00 EDT 1991}

}

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