Monoclonal antibodies: new agents for cancer detection and targeted therapy
- Univ. of Nottingham (United Kingdom)
Antibodies directed against markers on cancer cells are gaining in importance for the purpose of targeting diagnostic and therapeutic agents. In the past, this approach has had very limited success principally because the classical methods for producing antibodies from blood serum of animals immunized with cancer cells or extracts were unsatisfactory. The situation has changed dramatically since 1975 following the design of procedures for 'immortalizing' antibody-producing cells (lymphocytes) by fusing them with cultured myeloma cells to form hybridomas which continuously secrete antibodies. Since these hybridomas produce antibodies coded for by a single antibody-producing cell, the antibodies are called monoclonal. Building on these advances in biomedical research, it is now possible to reproducibly manufacture monoclonal antibodies on a scale suitable for use in cancer detection and therapy.
- OSTI ID:
- 5397465
- Journal Information:
- Cancer Detection and Prevention; (United States), Vol. 15:2; ISSN 0361-090X
- Country of Publication:
- United States
- Language:
- English
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MONOCLONAL ANTIBODIES
SPECIFICITY
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FORECASTING
LYMPHOCYTES
NEOPLASMS
RADIOIMMUNOSCINTIGRAPHY
RADIOIMMUNOTHERAPY
THERAPEUTIC USES
ANIMAL CELLS
ANTIBODIES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
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ISOTOPE APPLICATIONS
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NUCLEAR MEDICINE
RADIOIMMUNODETECTION
RADIOIMMUNOLOGY
RADIOISOTOPE SCANNING
RADIOLOGY
RADIOTHERAPY
SCINTISCANNING
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550601* - Medicine- Unsealed Radionuclides in Diagnostics
550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-)