The Langerhans cell

Wolff, K; Stingl, G

doi:10.1111/1523-1747.ep12536750

Title: The Langerhans cell

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Abstract

Langerhans cells are the bone-marrow-derived immune cells of the epidermis; they express Ia antigens and receptors for the Fc portion of IgG and complement components and are required for epidermal-cell-induced antigen-specific, syngeneic and allogeneic T-cell activitation and the generation of epidermal-cell-induced cytotoxic T cells. Their presence within the epidermis and functional integrity determine whether topical application of haptens leads to specific sensitization or unresponsiveness, and in skin grafts of only I region disparate donors, they represent the cells responsible for the critical allosensitizing signal. UV radiation abrogates most of Langerhans cell functions in vitro; under certain conditions in vivo, it prevents contact sensitization favoring the development of specific unresponsiveness. UV radiation abrogates antigen-presenting capacities of epidermal cells by interfering both with the processing of antigen by Langerhans cells and the production of the epidermal-cell-derived thymocyte activating factor required for optimal T-cell responses.

Authors:: Wolff, K; Stingl, G

Publication Date:: Wed Jun 01 00:00:00 EDT 1983

Research Org.:: Department of Dermatology I, University of Vienna, Austria

OSTI Identifier:: 5394832

Resource Type:: Journal Article

Journal Name:: J. Invest. Dermatol.; (United States)

Additional Journal Information:: Journal Volume: 80

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BONE MARROW CELLS; BIOLOGICAL RADIATION EFFECTS; EPIDERMIS; IMMUNITY; ULTRAVIOLET RADIATION; BIOLOGICAL EFFECTS; DERMATITIS; GRAFT-HOST REACTION; IMMUNOLOGY; LYMPHOCYTES; ANIMAL CELLS; ANIMAL TISSUES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DISEASES; ELECTROMAGNETIC RADIATION; EPITHELIUM; LEUKOCYTES; MATERIALS; ORGANS; RADIATION EFFECTS; RADIATIONS; SKIN; SKIN DISEASES; SOMATIC CELLS; TISSUES; 550300* - Cytology; 560121 - Radiation Effects on Cells- External Source- (-1987)

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                    Wolff, K, and Stingl, G. The Langerhans cell.  United States: N. p., 1983. 
        Web.  doi:10.1111/1523-1747.ep12536750.

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                    Wolff, K, & Stingl, G. The Langerhans cell.  United States.  https://doi.org/10.1111/1523-1747.ep12536750

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                    Wolff, K, and Stingl, G. 1983.  
        "The Langerhans cell".  United States.  https://doi.org/10.1111/1523-1747.ep12536750.

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@article{osti_5394832,

  title        = {The Langerhans cell},

  author       = {Wolff, K and Stingl, G},

  abstractNote = {Langerhans cells are the bone-marrow-derived immune cells of the epidermis; they express Ia antigens and receptors for the Fc portion of IgG and complement components and are required for epidermal-cell-induced antigen-specific, syngeneic and allogeneic T-cell activitation and the generation of epidermal-cell-induced cytotoxic T cells. Their presence within the epidermis and functional integrity determine whether topical application of haptens leads to specific sensitization or unresponsiveness, and in skin grafts of only I region disparate donors, they represent the cells responsible for the critical allosensitizing signal. UV radiation abrogates most of Langerhans cell functions in vitro; under certain conditions in vivo, it prevents contact sensitization favoring the development of specific unresponsiveness. UV radiation abrogates antigen-presenting capacities of epidermal cells by interfering both with the processing of antigen by Langerhans cells and the production of the epidermal-cell-derived thymocyte activating factor required for optimal T-cell responses.},

  doi          = {10.1111/1523-1747.ep12536750},

  url          = {https://www.osti.gov/biblio/5394832},
  journal      = {J. Invest. Dermatol.; (United States)},
number       = ,

  volume       = 80,

  place        = {United States},

  year         = {Wed Jun 01 00:00:00 EDT 1983},

  month        = {Wed Jun 01 00:00:00 EDT 1983}

}

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