RTOG phase I study on fast neutron teletherapy for squamous cell carcinoma of the esophagus

Journal Article · Fri Apr 01 00:00:00 EST 1983 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(83)90062-7· OSTI ID:5391620

Laramore, G E ^[1]; Davis, R B; Olson, M H; Cohen, L; Raghaven, V; Griffin, T W; Rogers, C C; Al-Abdulla, A S.M.; Gahbauer, R A; Davis, L W

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1. Univ. of Washington Hospital, Seattle

From August, 1977, though January, 1981, the Radiation Therapy Oncology Goup sponsored a Pase I study (RTOG 77-09) on the use of fast neutrons for treating inoperable squamous cell carcinomas of the esophagus. A total of 39 evaluable patients were treated with curative intent using either fast neutrons alone or in combination with low LET irradiation as part of a mixed beam fractionation scheme. Actuarial survival curves are presented for both the ''neutrons alone'' and the ''mixed beam'' treatment goups. There was no significant survival difference between these goups of patients. The projected survival at two years is less than 10%, which is comparable weth megavoltage photon results for an unselected series of patients. The size of the primary lesion and the initial Karnofsky performance status were found to be the most important prognostic indications for prolonged survival. Sixteen of 39 patients were felt to have achieved local clearance of their tumor at some time during their follow-up with the median time until a local recurrence being 17 months. Treatment related complications and patterns of metastatic spread are discussed. In general, it appeared that the response of large tumors to neutron irradiation resulted in necrosis and fistula formation. In many cases this was accompanied by persistent/ recurrent tumor within the high dose radiation volume.

• OSTI ID: 5391620
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 9:4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
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DELAYED RADIATION EFFECTS
FISTULAE
RADIOINDUCTION
NECROSIS
NEUTRON THERAPY
SIDE EFFECTS
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NEUTRONS
NUCLEAR MEDICINE
NUCLEONS
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIOLOGY
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560151* - Radiation Effects on Animals- Man
550603 - Medicine- External Radiation in Therapy- (1980-)