Dosimetry modeling of inhaled toxic reactive gases
This report focuses on the physical, chemical, and biological processes and factors involved in the absorption of reactive gases. Emphasis is placed on the importance of these factors in developing dosimetry models, special consideration being given to the role of lung fluids and tissues. Several dosimetry models are discussed and illustrations of predicted results presented to demonstrate the application of the models to the uptake of NO/sub 2/ and O/sub 3/, and to demonstrate the use of models in determining the effects of physical, chemical and biological parameters on dosimetry predictions. Gaps in our knowledge and understanding of the processes of dosimetry are pointed out, and research recommendations are made to increase our understanding of the processes and to enhance the development of dosimetry models.
- Research Organization:
- Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
- OSTI ID:
- 5391124
- Report Number(s):
- PB-86-220365/XAB; EPA/600/D-86/143
- Country of Publication:
- United States
- Language:
- English
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