Longitudinal studies of blood lymphocyte capacity in Hodgkin's disease

Journal Article · Sun Nov 01 00:00:00 EST 1981 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19811101)48:9<2010::AID-CNCR2820480917>3.0.CO;2-V· OSTI ID:5388713

Bjoerkholm, M; Wedelin, C; Holm, G; Johansson, B; Mellstedt, H

Blood lymphocyte functional capacity and serum immunoglobulins were studied in 40 patients with Hodgkin's disease (HD) admitted to Radiumhemmet, Stockholm, before treatment and in complete remission 2-56 months following termination of radiotherapy (total nodal irradiation (TNI); n . 29) or chemotherapy (MOPP; n . 11). Lymphocyte studies included determination of total lymphocyte and T-cell counts and evaluation of spontaneous DNA synthesis during the first day of culture and mitogen-(concanavalin A, pokeweed mitogen) and antigen (purified protein derivative, PPD)-induced activation on the third day. Blood lymphocyte and T-cell counts decreased dramatically following TNI. A slow restitution was seen, but pretreatment levels were not reached even four years following therapy. The responses to ConA and PPD but not PWM were significantly reduced shortly after TNI. The mitogen response did not increase with time as did the PPD response. Lymphocyte counts and lymphocyte stimulation, which were severely depressed before treatment of patients in the chemotherapy group, remained unchanged 2-36 months after termination of therapy. A significant reduction of IgM levels was observed regardless of the mode of treatment. Splenectomy prevented the profound reduction of blood lymphocyte and T-cell counts following therapy but did not influence the other immunologic variables under study.

• Research Organization: Department of Medicine, Danderyd's Hospital, Sweden
• OSTI ID: 5388713
• Journal Information: Cancer (Philadelphia); (United States), Vol. 48:9
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
HODGKINS DISEASE
PATHOLOGY
IMMUNOGLOBULINS
BIOCHEMISTRY
LYMPH NODES
BIOLOGICAL RADIATION EFFECTS
LYMPHOCYTES
CHEMOTHERAPY
PATIENTS
RADIOTHERAPY
WHOLE-BODY IRRADIATION
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHEMISTRY
CONNECTIVE TISSUE CELLS
DISEASES
EXTERNAL IRRADIATION
GLOBULINS
IRRADIATION
LEUKOCYTES
LYMPHATIC SYSTEM
LYMPHOMAS
MATERIALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
PROTEINS
RADIATION EFFECTS
RADIOLOGY
SOMATIC CELLS
THERAPY
560151* - Radiation Effects on Animals- Man
550200 - Biochemistry
551000 - Physiological Systems