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Title: Effect of protein quality on /sup 14/C glucose utilization in isolated rat mammary acini

Abstract

Poor protein quality has a deleterious effect on lactation in rats. Dams consuming a 13% wheat gluten (WG) diet are unable to maintain litters. Glucose utilization in isolated mammary acini taken from dams at either day 20 of gestation (G20) or day 4 of lactation (L4) was examined in dams consuming 13% WG vs 13% casein-methionine (CM) diets from day of breeding. Dams consuming WG had significantly smaller inguinal-abdominal mammary glands than CM dams at both G20 and L4, and mammary glands of CM but not WG dams were larger at L4 than G20. Both average pup weight and pup daily gain were smaller in WG litters. Basal levels of /sup 14/C glucose oxidation (GO) and /sup 14/C glucose incorporation into lipid (GL) and lactose were examined. A large significant increase in GO and GL occurred in CM dams from G20 to L4 but not in WG dams. Both GO and GL were higher in CM dams on L4 but not at G20. The ratio of GO:GO+GL changed at parturition in CM but not WG dams. The normal changes in glucose utilization by mammary epithelial cells which occur at parturition were impaired by the WG diet.

Authors:
; ;
Publication Date:
Research Org.:
Colorado State Univ., Fort Collins
OSTI Identifier:
5384402
Report Number(s):
CONF-8604222-
Journal ID: CODEN: FEPRA; TRN: 86-026677
Resource Type:
Conference
Journal Name:
Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
Additional Journal Information:
Journal Volume: 45:3; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; GLUCOSE; METABOLISM; PROTEINS; BIOLOGICAL EFFECTS; CARBON 14 COMPOUNDS; CASEIN; DIET; EPITHELIUM; LACTATION; MAMMARY GLANDS; METHIONINE; RATS; TRACER TECHNIQUES; ALDEHYDES; AMINO ACIDS; ANIMAL TISSUES; ANIMALS; BODY; CARBOHYDRATES; CARBOXYLIC ACIDS; DRUGS; GLANDS; HEXOSES; ISOTOPE APPLICATIONS; LABELLED COMPOUNDS; LIPOTROPIC FACTORS; MAMMALS; MONOSACCHARIDES; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC PHOSPHORUS COMPOUNDS; ORGANIC SULFUR COMPOUNDS; ORGANS; RODENTS; SACCHARIDES; TISSUES; VERTEBRATES; 550501* - Metabolism- Tracer Techniques

Citation Formats

Masor, M L, Grundleger, M L, and Jansen, G R. Effect of protein quality on /sup 14/C glucose utilization in isolated rat mammary acini. United States: N. p., 1986. Web.
Masor, M L, Grundleger, M L, & Jansen, G R. Effect of protein quality on /sup 14/C glucose utilization in isolated rat mammary acini. United States.
Masor, M L, Grundleger, M L, and Jansen, G R. 1986. "Effect of protein quality on /sup 14/C glucose utilization in isolated rat mammary acini". United States.
@article{osti_5384402,
title = {Effect of protein quality on /sup 14/C glucose utilization in isolated rat mammary acini},
author = {Masor, M L and Grundleger, M L and Jansen, G R},
abstractNote = {Poor protein quality has a deleterious effect on lactation in rats. Dams consuming a 13% wheat gluten (WG) diet are unable to maintain litters. Glucose utilization in isolated mammary acini taken from dams at either day 20 of gestation (G20) or day 4 of lactation (L4) was examined in dams consuming 13% WG vs 13% casein-methionine (CM) diets from day of breeding. Dams consuming WG had significantly smaller inguinal-abdominal mammary glands than CM dams at both G20 and L4, and mammary glands of CM but not WG dams were larger at L4 than G20. Both average pup weight and pup daily gain were smaller in WG litters. Basal levels of /sup 14/C glucose oxidation (GO) and /sup 14/C glucose incorporation into lipid (GL) and lactose were examined. A large significant increase in GO and GL occurred in CM dams from G20 to L4 but not in WG dams. Both GO and GL were higher in CM dams on L4 but not at G20. The ratio of GO:GO+GL changed at parturition in CM but not WG dams. The normal changes in glucose utilization by mammary epithelial cells which occur at parturition were impaired by the WG diet.},
doi = {},
url = {https://www.osti.gov/biblio/5384402}, journal = {Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)},
number = ,
volume = 45:3,
place = {United States},
year = {Sat Mar 01 00:00:00 EST 1986},
month = {Sat Mar 01 00:00:00 EST 1986}
}

Conference:
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