Myocardial blood flow during induced aortic hypertension in dogs
Abstract
Myocardial blood flow was measured in anesthetized dogs during control conditions and under conditions where the aortic pressure was increased due to aortic constriction or during infusion. Blood flow was measured using the radioactive microsphere technique. Radioactive microspheres (15 m Ce-141, Sr-85, and Sc-46) were injected under control, aortic constriction and arterenol infusion in four dogs and under control conditions in two others. All microsphere injections were performed under stabilized conditions. It was found that coronary blood flow rose by 80% during aortic constriction and by 158% during arterenol infusion (P < 0.05). This increase in blood flow was not uniform throughout the heart, and higher increases were observed in the middle and apex regions of the left ventricle. Furthermore, under hypertension the increase in blood flow in LAD (left anterior descending) perfused territories was slightly higher than that in CFX (left circumflex) perfused territories.
- Authors:
- Publication Date:
- Research Org.:
- Univ. of Houston, TX
- OSTI Identifier:
- 5383303
- Report Number(s):
- CONF-8604222-
Journal ID: CODEN: FEPRA; TRN: 86-026731
- Resource Type:
- Conference
- Journal Name:
- Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
- Additional Journal Information:
- Journal Volume: 45:3; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; AORTA; VASOCONSTRICTION; HYPERTENSION; PATHOGENESIS; MYOCARDIUM; BLOOD FLOW; BLOOD PRESSURE; DOGS; MICROSPHERES; RADIOISOTOPES; ANIMALS; ARTERIES; BLOOD VESSELS; BODY; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; DISEASES; HEART; ISOTOPES; MAMMALS; MUSCLES; ORGANS; SYMPTOMS; VASCULAR DISEASES; VERTEBRATES; 550901* - Pathology- Tracer Techniques
Citation Formats
Thai, B N, Levesque, M J, and Nerem, R M. Myocardial blood flow during induced aortic hypertension in dogs. United States: N. p., 1986.
Web.
Thai, B N, Levesque, M J, & Nerem, R M. Myocardial blood flow during induced aortic hypertension in dogs. United States.
Thai, B N, Levesque, M J, and Nerem, R M. 1986.
"Myocardial blood flow during induced aortic hypertension in dogs". United States.
@article{osti_5383303,
title = {Myocardial blood flow during induced aortic hypertension in dogs},
author = {Thai, B N and Levesque, M J and Nerem, R M},
abstractNote = {Myocardial blood flow was measured in anesthetized dogs during control conditions and under conditions where the aortic pressure was increased due to aortic constriction or during infusion. Blood flow was measured using the radioactive microsphere technique. Radioactive microspheres (15 m Ce-141, Sr-85, and Sc-46) were injected under control, aortic constriction and arterenol infusion in four dogs and under control conditions in two others. All microsphere injections were performed under stabilized conditions. It was found that coronary blood flow rose by 80% during aortic constriction and by 158% during arterenol infusion (P < 0.05). This increase in blood flow was not uniform throughout the heart, and higher increases were observed in the middle and apex regions of the left ventricle. Furthermore, under hypertension the increase in blood flow in LAD (left anterior descending) perfused territories was slightly higher than that in CFX (left circumflex) perfused territories.},
doi = {},
url = {https://www.osti.gov/biblio/5383303},
journal = {Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)},
number = ,
volume = 45:3,
place = {United States},
year = {Sat Mar 01 00:00:00 EST 1986},
month = {Sat Mar 01 00:00:00 EST 1986}
}