Further studies on the late preventive effects of the anticalmodulin trifluoperazine on carbon tetrachloride-induced liver necrosis
The authors previously reported that trifluorperazine (TFP) administration 6 or 10 hr after CCl/sub 4/ is able to partially prevent liver necrosis by the hepatotoxin at 24 hr. Preventive effect is not due to interference by TFP on CCl/sub 4/ metabolic activation to CCl/sub 3/ or its covalent binding to cellular components or of lipid peroxidation. Now the authors report that TFP administration 10 hr after CCl/sub 4/ does not prevent calcium accumulation but increases glycogen content. Increases in glycogen are more marked in livers of animals receiving only TFP. Administration slightly stimulates /sup 14/C-leucine incorporation in liver proteins but it does not modify decay of radioactivity in (/sup 14/C-guanidino) arginine prelabelled liver protein. TFP does not modify decay of radioactivity in /sup 32/P prelabelled phospholipid. Electron microscopy studies of livers from CCl/sub 4/ poisoned rats receiving TFP 10 hr after the hepatoto toxin and sacrificed at 24 hr revealed the presence of glycogen granules in otherwise glycogen-depleted preparations. These preparations showed only slight dilatation of the endoplasmic reticulum or the perinuclear membrane and intact mitochondria. Results might suggest that TFP interaction with calmodulin might interfere with a process of propagation of CCl/sub 4/-induced liver damage sparked by calcium accumulation and requiring the hormone for operation.
- Research Organization:
- CEITOX, Villa Martelli, Argentina
- OSTI ID:
- 5382087
- Report Number(s):
- CONF-8604222-; TRN: 86-026822
- Journal Information:
- Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:3; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
ANTIDEPRESSANTS
BIOLOGICAL EFFECTS
CARBON TETRACHLORIDE
METABOLIC ACTIVATION
TOXICITY
LIVER
NECROSIS
CARBON 14 COMPOUNDS
CELL MEMBRANES
COVALENCE
ELECTRON MICROSCOPY
ENDOPLASMIC RETICULUM
GLYCOGEN
LEUCINE
MITOCHONDRIA
PHOSPHOLIPIDS
PHOSPHORUS 32
RATS
TRACER TECHNIQUES
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOHYDRATES
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CENTRAL NERVOUS SYSTEM AGENTS
CHLORINATED ALIPHATIC HYDROCARBONS
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DRUGS
ESTERS
GLANDS
HALOGENATED ALIPHATIC HYDROCARBONS
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
LIPIDS
MAMMALS
MEMBRANES
MICROSCOPY
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANOIDS
ORGANS
PATHOLOGICAL CHANGES
PHOSPHORUS ISOTOPES
POLYSACCHARIDES
PSYCHOTROPIC DRUGS
RADIOISOTOPES
RODENTS
SACCHARIDES
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550501 - Metabolism- Tracer Techniques