(Non-invasive evaluation of the cardiac autonomic nervous system by PET)

Title: (Non-invasive evaluation of the cardiac autonomic nervous system by PET)

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Abstract

Our research efforts in the first funding year concentrated on animal and clinical studies validating {sup 11}C-hydroxyephedrine as a marker for norepinephrine uptake and storage in presynaptic sympathetic nerve terminals. In addition to kinetic studies in animals, the first clinical studies have been performed. {sup 11}C-hydroxyephedrine provides excellent image quality in the human heart with high myocardium to blood ratios. A canine model with transient intracoronary occlusion of the left anterior descending aorta was used to show decreased retention of tracer with ischemia. Clinical studies of patients with acute myocardial infarction showed an area of decreased retention of tracer exceeding the infarct territory as defined by {sup 82}Rb blood flow imaging. We are also developing tracers for the parasympathetic nervous system. It appears that methyl-TRB is a specific tracer for this system. Studies of {sup 11}C- or {sup 18}F-benzovesamicol as a potential tracer for parasympathetic presynaptic nerve terminals are under way. (MHB)

Publication Date:: Tue Jan 01 00:00:00 EST 1991

Research Org.:: Michigan Univ., Ann Arbor, MI (United States). Div. of Nuclear Medicine

Sponsoring Org.:: USDOE; USDOE, Washington, DC (United States)

OSTI Identifier:: 5381369

Report Number(s):: DOE/ER/61091-1
ON: DE91018476

DOE Contract Number:: FG02-90ER61091

Resource Type:: Technical Report

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; CARDIOVASCULAR DISEASES; DIAGNOSIS; HEART; POSITRON COMPUTED TOMOGRAPHY; RADIOPHARMACEUTICALS; TRACER TECHNIQUES; AUTONOMIC NERVOUS SYSTEM; BIOLOGICAL MODELS; BLOOD FLOW; CARBON 11; EPHEDRINE; FLUORINE 18; HISTOLOGY; LABELLING; MYOCARDIUM; PROGRESS REPORT; RADIONUCLIDE KINETICS; RECEPTORS; RUBIDIUM 82; SCINTISCANNING; TISSUE DISTRIBUTION; ALKALI METAL ISOTOPES; ALKALOIDS; AMINES; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CARBON ISOTOPES; CARDIOVASCULAR AGENTS; CARDIOVASCULAR SYSTEM; COMPUTERIZED TOMOGRAPHY; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DISEASES; DISTRIBUTION; DOCUMENT TYPES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; EVEN-ODD NUCLEI; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; HYDROXY COMPOUNDS; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MEMBRANE PROTEINS; MINUTES LIVING RADIOISOTOPES; MUSCLES; NANOSEC LIVING RADIOISOTOPES; NERVOUS SYSTEM; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIOISOTOPE SCANNING; RADIOISOTOPES; RUBIDIUM ISOTOPES; SYMPATHOMIMETICS; TOMOGRAPHY; VASOCONSTRICTORS; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 551000 - Physiological Systems

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                    . (Non-invasive evaluation of the cardiac autonomic nervous system by PET).  United States: N. p., 1991. 
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                    . (Non-invasive evaluation of the cardiac autonomic nervous system by PET).  United States.

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                    . 1991.  
        "(Non-invasive evaluation of the cardiac autonomic nervous system by PET)".  United States.

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@article{osti_5381369,

  title        = {(Non-invasive evaluation of the cardiac autonomic nervous system by PET)},

  author       = {},

  abstractNote = {Our research efforts in the first funding year concentrated on animal and clinical studies validating {sup 11}C-hydroxyephedrine as a marker for norepinephrine uptake and storage in presynaptic sympathetic nerve terminals. In addition to kinetic studies in animals, the first clinical studies have been performed. {sup 11}C-hydroxyephedrine provides excellent image quality in the human heart with high myocardium to blood ratios. A canine model with transient intracoronary occlusion of the left anterior descending aorta was used to show decreased retention of tracer with ischemia. Clinical studies of patients with acute myocardial infarction showed an area of decreased retention of tracer exceeding the infarct territory as defined by {sup 82}Rb blood flow imaging. We are also developing tracers for the parasympathetic nervous system. It appears that methyl-TRB is a specific tracer for this system. Studies of {sup 11}C- or {sup 18}F-benzovesamicol as a potential tracer for parasympathetic presynaptic nerve terminals are under way. (MHB)},

  doi          = {},

  url          = {https://www.osti.gov/biblio/5381369},
  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Jan 01 00:00:00 EST 1991},

  month        = {Tue Jan 01 00:00:00 EST 1991}

}

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