Radioimmunoimaging of venous thrombi using iodine-131 monoclonal antibody. [Dogs]

Conference · Thu Aug 01 00:00:00 EDT 1985 · Radiology; (United States)

OSTI ID:5379751

Rosebrough, S F; Kudryk, B; Grossman, Z D; McAfee, J G; Subramanian, G; Ritter-Hrncirik, C A; Witanowski, L S; Tillapaugh-Fay, G

Murine monoclonal antibody (Mab) specific for the NH/sub 2/-terminal region of human fibrin, but not cross-reactive with fibrinogen, was used in radioimmuno-imaging of fresh, induced venous thrombi in three dogs. Iodine-131-labeled Mab was injected intravenously, with iodine 125-labeled polyclonal murine gamma-G globulin (IgG) simultaneously injected as a control. Images were strongly positive at 24 and 48 hours in all three animals, with thrombus-to-blood and thrombus-to-muscle ratios of 8.4 and 228.0, respectively, for I-131-labeled Mab; these ratios for control IgG were 1.2 and 13.0. Radioimmunodetection of thrombi in vivo is feasible in dogs and may have clinical application since Mab is specific to human fibrin.

• Research Organization: State Univ. of New York, Syracuse
• OSTI ID: 5379751
• Report Number(s): CONF-851152-
• Journal Information: Radiology; (United States), Vol. 156:2; Conference: 71. scientific assembly and annual meeting, Chicago, IL, USA, 17 Nov 1985
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
IODINE 131
TISSUE DISTRIBUTION
MONOCLONAL ANTIBODIES
THROMBOSIS
DIAGNOSIS
BLOOD
DOGS
FIBRIN
IMMUNOGLOBULINS
IODINE 125
MUSCLES
ANIMALS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY FLUIDS
CARDIOVASCULAR DISEASES
COAGULANTS
DAYS LIVING RADIOISOTOPES
DISEASES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GLOBULINS
HEMATOLOGIC AGENTS
HEMOSTATICS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MAMMALS
MATERIALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PROTEINS
RADIOISOTOPES
SCLEROPROTEINS
VASCULAR DISEASES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics