Effect of dietary copper and sucrose on catecholamine concentrations in the adrenal medulla

Conference · Mon Mar 11 00:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5371818

Koo, S I; Peterson, D F; Mason, P A ^[1]

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1. Kansas State Univ., Manhattan (United States) KCOM, Kirksville, MO (United States) Air Force/SAM/RZP, Brooks AFB, TX (United States)

The severity of copper (Cu) deficiency in the rat is enhanced by dietary sucrose. Possible interactive effects of Cu status and sucrose on catecholamine concentrations in the adrenal medulla were investigated in Cu deficient rats fed a diet were investigated in Cu deficient rats fed a diet containing either glucose or sucrose, as compared with respective Cu-adequate controls. Catecholamines were analyzed by an HPLC method using 3,4-dihydroxybenxylamine as the internal standard. Cu deficiency caused pronounced decreases in norepinephrine and epinephrine, with no significant effect on dopamine, as expressed in nmoles/mg tissue. Dietary sucrose showed no appreciable effect on catecholamines in the adrenal medulla. The adrenal glands were markedly enlarged in Cu-deficient rats, whether fed glucose or sucrose. Adrenal weights were not affected by dietary sucrose. Data indicate that the increased severity of copper deficiency due to sucrose feeding is not associated with changes in adrenal catecholamine output.

• OSTI ID: 5371818
• Report Number(s): CONF-9104107-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:4; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL GLANDS
PATHOLOGICAL CHANGES
CATECHOLAMINES
BIOSYNTHESIS
COPPER
BIOLOGICAL EFFECTS
SACCHAROSE
LIQUID COLUMN CHROMATOGRAPHY
METABOLISM
NUTRITIONAL DEFICIENCY
RATS
AMINES
ANIMALS
AROMATICS
BODY
CARBOHYDRATES
CHROMATOGRAPHY
DISACCHARIDES
ELEMENTS
ENDOCRINE GLANDS
GLANDS
HYDROXY COMPOUNDS
MAMMALS
METALS
OLIGOSACCHARIDES
ORGANIC COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
RODENTS
SACCHARIDES
SEPARATION PROCESSES
SYNTHESIS
TRANSITION ELEMENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology