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Title: Basis for new strategies in postoperative radiotherapy of bronchogenic carcinoma

Abstract

In order to improve our understanding of the role of postoperative radiotherapy and to search for new strategies in the management of N/sub 1/, N/sub 2/, T/sub 3/ stage carcinoma of the lung, we analyzed results of treatment in 148 of 166 patients who were registered at the Massachusetts General Hospital Tumor Registry from 1971 to 1977 with a pathological diagnosis of N/sub 1/, N/sub 2/, T/sub 3/ carcinoma of the lung after pulmonary resection. Ninety-three patients received postoperative radiotherapy and another 55 were followed without further treatment. Patients with adenocarcinoma showed significant improvement of survival by postoperative radiotherapy; actuarial NED (no evidence of disease) survival rates were 85% and 51% at 1 year, and 43% and 8% at 5 years for S + RT (patients treated with surgery plus postoperative radiotherapy) and S (patients treated with surgery only) groups, respectively, (P < 0.01). The brain was the most common site of failure in adenocarcinoma, 53% and 58% of all failures occurred in the brain in S and S + RT groups suggesting elective whole brain irradiation in a future trial. For the squamous cell carcinoma group, there was no improved survival in the irradiated patients, actuarial NED survival ratesmore » were 63% for both S + RT and S groups at 2 years, and 42% and 33% for S + RT and S groups at 4 years. These figures should be considered in the light of the following: In 52% (24/46) of S + RT vs. 27% (8/29) of S group, disease was in N/sub 2/, T/sub 3/ stages. Regional recurrence was the most common failure in squamous cell carcinoma; 76% (13/17) and 45% (10/22) of all failures were in the regional area in S and S + RT groups. Regional failure in S + RT group was noted with radiation dose up to 5000 rad (TDF 82) which suggests radiation dose higher than 5000 rad in future trial.« less

Authors:
; ; ; ;
Publication Date:
Research Org.:
Massachusetts General Hospital, Boston
OSTI Identifier:
5370563
Resource Type:
Conference
Journal Name:
Int. J. Radiat. Oncol., Biol. Phys.; (United States)
Additional Journal Information:
Journal Volume: 6:1; Conference: American Society of Therapeutic Radiologists annual meeting, Los Angeles, CA, USA, 1 Nov 1978
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; LUNGS; BIOLOGICAL RADIATION EFFECTS; MYELITIS; RADIOINDUCTION; NAUSEA; NERVOUS SYSTEM; PNEUMONITIS; RADIOTHERAPY; SIDE EFFECTS; ADRENAL GLANDS; AGE DEPENDENCE; BRAIN; CARCINOMAS; DATA COMPILATION; FAILURES; GRAPHS; PATIENTS; RADIATION DOSES; SEX DEPENDENCE; SURGERY; SURVIVAL CURVES; SURVIVAL TIME; TABLES; BIOLOGICAL EFFECTS; BODY; CENTRAL NERVOUS SYSTEM; DATA; DATA FORMS; DISEASES; DOSES; ENDOCRINE GLANDS; GLANDS; INFORMATION; MEDICINE; NEOPLASMS; NERVOUS SYSTEM DISEASES; NUCLEAR MEDICINE; NUMERICAL DATA; ORGANS; RADIATION EFFECTS; RADIOLOGY; RESPIRATORY SYSTEM; SYMPTOMS; THERAPY; 560151* - Radiation Effects on Animals- Man; 550603 - Medicine- External Radiation in Therapy- (1980-)

Citation Formats

Choi, N C.H., Grillo, H C, Gardiello, M, Scannel, J G, and Wilkins, Jr, E W. Basis for new strategies in postoperative radiotherapy of bronchogenic carcinoma. United States: N. p., 1980. Web.
Choi, N C.H., Grillo, H C, Gardiello, M, Scannel, J G, & Wilkins, Jr, E W. Basis for new strategies in postoperative radiotherapy of bronchogenic carcinoma. United States.
Choi, N C.H., Grillo, H C, Gardiello, M, Scannel, J G, and Wilkins, Jr, E W. 1980. "Basis for new strategies in postoperative radiotherapy of bronchogenic carcinoma". United States.
@article{osti_5370563,
title = {Basis for new strategies in postoperative radiotherapy of bronchogenic carcinoma},
author = {Choi, N C.H. and Grillo, H C and Gardiello, M and Scannel, J G and Wilkins, Jr, E W},
abstractNote = {In order to improve our understanding of the role of postoperative radiotherapy and to search for new strategies in the management of N/sub 1/, N/sub 2/, T/sub 3/ stage carcinoma of the lung, we analyzed results of treatment in 148 of 166 patients who were registered at the Massachusetts General Hospital Tumor Registry from 1971 to 1977 with a pathological diagnosis of N/sub 1/, N/sub 2/, T/sub 3/ carcinoma of the lung after pulmonary resection. Ninety-three patients received postoperative radiotherapy and another 55 were followed without further treatment. Patients with adenocarcinoma showed significant improvement of survival by postoperative radiotherapy; actuarial NED (no evidence of disease) survival rates were 85% and 51% at 1 year, and 43% and 8% at 5 years for S + RT (patients treated with surgery plus postoperative radiotherapy) and S (patients treated with surgery only) groups, respectively, (P < 0.01). The brain was the most common site of failure in adenocarcinoma, 53% and 58% of all failures occurred in the brain in S and S + RT groups suggesting elective whole brain irradiation in a future trial. For the squamous cell carcinoma group, there was no improved survival in the irradiated patients, actuarial NED survival rates were 63% for both S + RT and S groups at 2 years, and 42% and 33% for S + RT and S groups at 4 years. These figures should be considered in the light of the following: In 52% (24/46) of S + RT vs. 27% (8/29) of S group, disease was in N/sub 2/, T/sub 3/ stages. Regional recurrence was the most common failure in squamous cell carcinoma; 76% (13/17) and 45% (10/22) of all failures were in the regional area in S and S + RT groups. Regional failure in S + RT group was noted with radiation dose up to 5000 rad (TDF 82) which suggests radiation dose higher than 5000 rad in future trial.},
doi = {},
url = {https://www.osti.gov/biblio/5370563}, journal = {Int. J. Radiat. Oncol., Biol. Phys.; (United States)},
number = ,
volume = 6:1,
place = {United States},
year = {Tue Jan 01 00:00:00 EST 1980},
month = {Tue Jan 01 00:00:00 EST 1980}
}

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