Se-75-labeled bile acid analogs, new radiopharmaceuticals for investigating the enterohepatic circulation

Journal Article · Sat Aug 01 00:00:00 EDT 1981 · J. Nucl. Med.; (United States)

OSTI ID:5367250

Boyd, G S; Merrick, M V; Monks, R; Thomas, I L

Four selenium-labeled free bile acids and four selenium-labeled conjugated bile acids, labeled with Se-75 at the C-19, C-22, C-23, or C-24 position, have been synthesized and their absorption and excretion compared with that of (24-14C)cholic acid, following both oral and intravenous administration. All but one of the compounds is absorbed and excreted in bile to a significant extent. One compound, SeHCAT, has been selected for particular study. It is quantitatively absorbed from the gut at the same rate as cholic acid, and both are excreted into the bile at the same rate. It remains almost entirely confined to the enterohepatic circulation (the gut, liver, and biliary tree) and excretion is exclusively fecal. Whole-body retention, measured for 41 days, and tissue distributions suggest that the absorbed radiation dose would be small compared with that in many established tests. Such a compound offers the possibility of a simple, novel, and aesthetically acceptable method of investigating small-bowel disease. It therefore merits further investigation.

• OSTI ID: 5367250
• Journal Information: J. Nucl. Med.; (United States), Vol. 22:8
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BILIARY TRACT
SCINTISCANNING
DIGESTIVE SYSTEM DISEASES
DIAGNOSIS
LIVER
SELENIUM 75
DIAGNOSTIC USES
RADIONUCLIDE KINETICS
SMALL INTESTINE
BILE ACIDS
CARBON 14 COMPOUNDS
CHEMICAL PREPARATION
COMPARATIVE EVALUATIONS
EXCRETION
FECES
METABOLISM
RADIATION DOSES
RADIOPHARMACEUTICALS
TISSUE DISTRIBUTION
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
CARBOXYLIC ACIDS
CLEARANCE
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
DOSES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GASTROINTESTINAL TRACT
GLANDS
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
INTESTINES
ISOTOPES
LABELLED COMPOUNDS
MATERIALS
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SELENIUM ISOTOPES
STEROIDS
STEROLS
SYNTHESIS
USES
WASTES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
400702 - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials
551001 - Physiological Systems- Tracer Techniques
560171 - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987)